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Table of Contents

1. Introduction
2. Chemistry
3. Pharmacology
4. Dosage
5. Physical Effects
6. Cognitive Effects
7. Natural Sources
8. Toxicity and Harm Potential
9. Tolerance and Addiction Potential
10. Dangerous Interactions
11. Legal Status
12. FAQ (Frequently Asked Questions)

Introduction to Bufotenin

Bufotenin, also known as 5-HO-DMT, N,N-dimethylserotonin, or bufotenine, stands as a naturally occurring substituted tryptamine alkaloid and a potent serotonergic psychedelic drug. Structurally, it shares similarities with tryptamine and serotonin. This compound can be found across various flora and fauna, with notable concentrations in certain species of psychoactive toads, prominently the Colorado River toad.

Natural Occurrence and Distribution

The presence of bufotenin spans a wide range of biological sources, encompassing diverse plant and animal species. Among these, psychoactive toads, notably the Colorado River toad, are renowned for their high concentrations of bufotenin. However, bufotenin's occurrence isn't limited to amphibians; it's also found in various plant species.

Effects of Bufotenin

While bufotenin shares the serotonergic psychedelic properties with other compounds like LSD, its effects are often described as less pleasant. Users commonly report a range of psychoactive effects, including hallucinations, altered perception, and changes in cognition and mood. However, compared to other psychedelics, bufotenin may induce more uncomfortable experiences.

Conclusion

In conclusion, bufotenin emerges as a naturally occurring psychedelic compound found in various biological sources, including certain species of toads and plants. Its serotonergic properties contribute to its psychedelic effects, albeit often characterized as less enjoyable compared to other substances of its class. Understanding bufotenin's natural occurrence and effects contributes to the broader knowledge of psychedelics in both scientific and recreational contexts.

Bufotenin Chemistry

Molecular Structure

Bufotenin, also known as 5-HO-DMT or 5-hydroxy-N,N-dimethyltryptamine, belongs to the tryptamine class of molecules. Tryptamines are characterized by a core structure comprising a bicyclic indole heterocycle attached at R3 to a terminal amine group via an ethyl side chain. Bufotenin is specifically substituted at R5 of its indole heterocycle with a hydroxy (OH) functional group, and it contains two methyl groups (CH3) bound to the terminal amine RN of its tryptamine backbone (DMT).

Pharmacology

Bufotenin's distribution and metabolism vary between different species, with studies primarily conducted on rats and limited data available for humans. In rats, subcutaneous administration of bufotenin leads to its distribution primarily to the lungs, heart, blood, and to a lesser extent, the brain (including regions such as the hypothalamus, brain stem, striatum, and cerebral cortex), and liver. Peak concentrations are reached within one hour, with elimination occurring within approximately 8 hours.

In humans, intravenous administration of bufotenin results in the excretion of approximately 70% of the injected drug in the form of 5-HIAA, an endogenous metabolite of serotonin, while roughly 4% is eliminated unmetabolized in the urine. Orally administered bufotenin undergoes extensive first-pass metabolism by the enzyme monoamine oxidase.

Bufotenin's primary psychedelic effects are believed to stem from its interaction with the 5-HT2A receptor as a partial agonist, exhibiting high binding affinity for the 5-HT2A and 5-HT1A subtypes. However, the precise mechanisms through which these interactions lead to the psychedelic experience remain incompletely understood.

Additionally, bufotenin may exert effects through mechanisms such as the inhibition of neurotransmitter reuptake, including serotonin, noradrenaline, and dopamine. Combining bufotenin with substances that act as monoamine oxidase inhibitors (MAOIs), reversible inhibitors of monoamine oxidase A (RIMAs), selective serotonin reuptake inhibitors (SSRIs), stimulants, or other substances that modulate monoamine neurotransmitters can potentially lead to dangerous toxicity.

Subjective Effects

It's important to note that the subjective effects of bufotenin are based on anecdotal user reports and the analysis of contributors to the Subjective Effect Index (SEI), and therefore should be approached with caution. The effects may not occur predictably or reliably, with higher doses increasing the likelihood of experiencing the full spectrum of effects. Adverse effects, including addiction, severe injury, or death, become more likely with higher doses.

Dosage of Bufotenin

Threshold

• Threshold dose: 2 mg

Light

• Light dose range: 5 - 20 mg

Common

• Common dose range: 20 - 40 mg

Strong

• Strong dose range: 40 - 60 mg

Heavy

• Heavy dose: 60 mg and above

These dosage guidelines provide an overview of the typical amounts of bufotenin consumed and the corresponding levels of effects experienced. It's important to note that individual responses to bufotenin can vary widely, and factors such as tolerance, body weight, and overall health should be considered when determining dosage. Additionally, caution should be exercised when consuming bufotenin, especially at higher doses, due to the potential for intense psychedelic effects and adverse reactions.

Physical Effects of Bufotenin

Overview

The physical effects of Bufotenin encompass a spectrum of sensations that intensify with dosage. While cognitive and visual effects may be relatively mild in comparison, Bufotenin is known for inducing intensely overwhelming physical sensations, which can be interpreted as either pleasurable or uncomfortable.

Tactile Enhancement

• Description: Tactile enhancement is a profound sensation experienced during a Bufotenin trip, amplifying tactile sensations to an overwhelming extent. Users may perceive sensations akin to sustained and repeatable full-body orgasms, leading to difficulty in sustaining breathing. Despite the intensity, it's crucial to note that this does not pose a genuine risk of respiratory depression and is considered safe.

Bodily Control Enhancement

• Description: Bufotenin may enhance bodily control, resulting in increased awareness and sensitivity to bodily movements.

Bodily Pressures

• Description: Users may experience changes in bodily pressures, which can manifest as sensations of heaviness or lightness.

Changes in Gravity

• Description: Perception of changes in gravity may occur, altering the sensation of movement and orientation in space.

Euphoria

• Description: Euphoric sensations are common during a Bufotenin experience, contributing to overall mood enhancement.

Motor Control Loss

• Description: Loss of motor control may occur, leading to difficulties in coordinated movement.

Nausea

• Description: Nausea is a possible side effect of Bufotenin ingestion, although it varies in severity among users.

Perception of Bodily Heaviness

• Description: Users may perceive their bodies as heavy or weighted down, affecting their sense of physical presence.

Pupil Dilation

• Description: Pupil dilation is a physiological response to Bufotenin ingestion, resulting in enlarged pupils.

Skin Flushing

• Description: Skin flushing, characterized by reddening of the skin, may occur as a result of increased blood flow.

Temperature Regulation Suppression

• Description: Bufotenin may suppress the body's ability to regulate temperature, leading to sensations of warmth or coldness.

Vasoconstriction

• Description: Vasoconstriction, the narrowing of blood vessels, may occur, potentially affecting blood circulation.

Visual Effects of Bufotenin

Overview

The visual effects of Bufotenin, while present, may be comparatively underwhelming compared to its intense cognitive and physical effects.

Visual Acuity Enhancement and Suppression

• Description: Bufotenin can both enhance and suppress visual acuity, with the outcome seemingly random and influenced by setting.

Drifting (Morphing, Breathing, Melting, Flowing)

• Description: Similar to DMT, Bufotenin may induce drifting visual effects characterized by slow, smooth motion and intricate details.

Colour Enhancement and Shifting

• Description: Bufotenin may enhance colors and induce shifting color perceptions, adding vibrancy to the visual experience.

Environmental Orbism

• Description: Environmental orbism refers to the perception of spherical distortions in the visual field, altering the perception of space and depth.

Recursion

• Description: Recursion involves the perception of self-replicating patterns or images, adding complexity to the visual experience.

Geometry

• Description: Bufotenin may induce intricate geometric patterns, similar to DMT but potentially smaller in size and more likely to manifest in darkness or without distractions. These patterns may be brightly lit, multicolored, and exhibit a blend of organic and digital qualities.

Cognitive Effects of Bufotenin

Overview

The cognitive effects of Bufotenin encompass a wide range of experiences that can vary in intensity and subjective interpretation among users.

Amnesia

• Description: Bufotenin may induce temporary amnesia, causing users to have difficulty recalling events or experiences during the trip.

Analysis Enhancement

• Description: Users may experience enhanced analytical thinking, leading to deeper insights and understanding of concepts or ideas.

Anxiety

• Description: Anxiety is a potential side effect of Bufotenin ingestion, characterized by feelings of unease, nervousness, or fear.

Conceptual Thinking

• Description: Bufotenin may enhance conceptual thinking, allowing users to explore abstract ideas or concepts more deeply.

Delusion

• Description: Delusions, or false beliefs, may occur during a Bufotenin trip, leading users to hold irrational or unrealistic ideas.

Autonomous Voice Communication

• Description: Some users may experience autonomous voice communication, perceiving voices or messages that seem to originate from within themselves.

Emotion Enhancement

• Description: Bufotenin can enhance emotions, intensifying feelings of joy, sadness, excitement, or fear.

Increased Music Appreciation

• Description: Music may be perceived more intensely and appreciated on a deeper level during a Bufotenin trip, leading to enhanced auditory experiences.

Memory Suppression

• Description: Bufotenin may suppress memory recall, causing users to have difficulty remembering past events or experiences.

Ego Death

• Description: Ego death refers to the loss of the sense of self or identity, often accompanied by feelings of unity with the universe or dissolution of boundaries between self and others.

Mindfulness

• Description: Bufotenin may enhance mindfulness, allowing users to become more aware of their thoughts, emotions, and sensory experiences in the present moment.

Thought Connectivity

• Description: Users may experience enhanced connectivity between thoughts, leading to a sense of interconnectedness or unity of consciousness.

Time Distortion

• Description: Time distortion is a common effect of Bufotenin, causing users to perceive time as either slowing down or speeding up.

Unity and Interconnectedness

• Description: Bufotenin may induce feelings of unity and interconnectedness with the universe or with others, leading to a sense of oneness or harmony.

Wakefulness

• Description: Bufotenin is known to promote wakefulness, keeping users alert and conscious throughout the duration of the trip.

Auditory Effects of Bufotenin

Enhancements

• Description: Bufotenin may enhance auditory perception, making sounds more vivid, clear, or immersive.

Distortions

• Description: Auditory distortions, such as changes in pitch, tone, or volume, may occur during a Bufotenin trip, altering the perception of sound.

Hallucinations

• Description: Users may experience auditory hallucinations, perceiving sounds or voices that are not present in reality. These hallucinations can range from subtle distortions to vivid and immersive experiences.

Natural Sources of Bufotenin

Colorado River Toad

• Scientific Name: Incilius alvarius
• Common Names: Colorado River toad, Sonoran Desert toad
• Distribution: Found in northern Mexico and the southwestern United States
• Description: The Colorado River toad is a psychoactive amphibian known for its skin and venom, which contain 5-MeO-DMT and bufotenin.
• Defense Mechanism: The toad's primary defense system includes glands that produce a potent poison, capable of causing harm to predators. These parotoid glands also produce bufotenin and 5-MeO-DMT. The venom can be safely collected from these glands without harming the toad.

Toxicity and Harm Potential

• The toxicity and long-term health effects of recreational bufotenin use have not been extensively studied in scientific contexts, and the exact toxic dose remains unknown.
• Anecdotal evidence suggests that low to moderate doses of bufotenin, used sparingly, do not typically result in negative health effects. However, caution should always be exercised, and independent research conducted before consumption.
• Harm reduction practices are strongly recommended when using bufotenin or any other psychoactive substance.

Tolerance and Addiction Potential

• Bufotenin is not considered habit-forming, and the desire to use it may decrease with continued use.
• Tolerance to the effects of bufotenin develops rapidly after ingestion but diminishes relatively quickly, typically returning to baseline within a few hours. Bufotenin does not exhibit cross-tolerance with other psychedelics.

Dangerous Interactions

• Bufotenin may interact dangerously with certain substances, leading to adverse effects or even life-threatening situations.
• Examples of dangerous interactions include:
  • Lithium
  • Cannabis
  • Stimulants
  • Tramadol
• Deaths from bufotenin are rare, but excessive doses or combinations with certain drugs, such as MAOIs, RIMAs, or stimulants, can lead to injury or fatalities.

Legal Status

• Germany: Controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019.
• Switzerland: Not controlled under specific categories, potentially legal.
• United Kingdom: Classified as a Class A drug.
• United States: Classified as a Schedule I substance.

FAQ (Frequently Asked Questions)

1. What is Bufotenin?

Bufotenin, also known as 5-HO-DMT or bufotenine, is a naturally occurring psychedelic compound found in various plants and animals, including certain species of toads.

2. What are the effects of Bufotenin?

Bufotenin can induce a range of effects, including physical sensations such as tactile enhancement and bodily control enhancement, as well as cognitive effects like euphoria and time distortion. Visual effects may include changes in visual acuity and hallucinations.

3. Where does Bufotenin come from?

One of the primary natural sources of Bufotenin is the Colorado River toad (Incilius alvarius), which secretes Bufotenin-containing venom from its parotoid glands.

4. Is Bufotenin toxic?

The toxicity of Bufotenin has not been extensively studied, but anecdotal evidence suggests that low to moderate doses are generally well-tolerated. However, caution should always be exercised, and harm reduction practices should be employed.

5. Can Bufotenin cause addiction?

Bufotenin is not considered to be habit-forming, and the desire to use it may decrease with continued use. However, like other psychedelics, it can lead to psychological dependence in some individuals.

6. What are the dangerous interactions of Bufotenin?

Bufotenin may interact dangerously with certain substances, including lithium, cannabis, stimulants, and tramadol. Combining Bufotenin with these substances can increase the risk of adverse effects or life-threatening situations.

7. What is the legal status of Bufotenin?

The legal status of Bufotenin varies by country. In some places, such as the United States and the United Kingdom, it is classified as a controlled substance. However, in other countries, it may not be specifically regulated.