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Product Name: Methoxetamine
IUPAC Name: 1-[1-(3-methoxyphenyl)cyclohexyl]-piperidine
Other Names: Methoxetamine, MXE; 3-MeO-2'-oxo-PCE
Cas Number: 1239943-76-0
Molecular Formula: C15H21NO2
Molar Mass: 247.33 g/mol
Effect: dissociative hallucinogen
Purity of the substance: 99.9%
Physical properties: Crystalline powder
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Table of Contents

  1. The History
  2. Effects
  3. Dosage Guidelines
  4. Legal Status
  5. Pharmacology
  6. Chemistry
  7. The Methoxetamine Trip
  8. Conclusion
  9. FAQs

The History

MXE's history is relatively short, dating back to the early 2010s when it first appeared on the research chemical market. Initially synthesized by pharmaceutical researchers, MXE gained popularity in the scientific community for its potential use in studying the N-methyl-D-aspartate (NMDA) receptor associated with learning and memory processes.

However, MXE's journey didn't stop in laboratories. It quickly entered recreational and party scenes, earning a reputation for its psychedelic and dissociative properties. Its legality and availability made it an attractive alternative to more traditional substances like ketamine.


Methoxetamine's effects are diverse and intriguing, offering users a unique and sometimes profound experience. These effects typically include:

  1. Dissociation: MXE is known for its dissociative solid properties. Users often feel disconnected from their bodies and may experience "out-of-body" sensations. This effect can lead to a dream-like state where the boundaries between self and the external world become blurred.
  2. Altered Perception: Perception of time, space, and reality can become distorted under the influence of MXE. Colors, sounds, and textures may appear more vivid and intense, creating heightened sensory awareness.
  3. Euphoria: Many users report feelings of ecstasy and bliss while on MXE. This can make it appealing for recreational purposes and induce a sense of well-being and pleasure.
  4. Enhanced Creativity: Some users find that MXE enhances creativity and thought processes. It may lead to introspection and deep contemplation.
  5. Physical Effects: MXE can cause motor impairment, making moving or coordinating movements difficult. It may also induce numbness and muscle relaxation.
  6. Hallucinations: MXE can produce vivid and sometimes unsettling hallucinations at higher doses. These can be visual, auditory, or even tactile.
  7. Mindset and Setting: As with many psychoactive substances, the user's perspective and the environment in which MXE is consumed can significantly influence the experience. A positive and safe setting is recommended.

Dosage Guidelines

MXE has a relatively wide dosage range, with effects varying significantly depending on the amount consumed. It's essential to start with a low dose and gradually increase if necessary, as individual tolerance and sensitivity can vary. Here are some general dosage guidelines:

  • Threshold: 5-10 mg
  • Light: 10-30 mg
  • Common: 20-50 mg
  • Strong: 40-100 mg
  • Heavy/Dissociative Anesthesia: 80-200 mg

MXE is typically consumed orally but can also be insufflated (snorted) or used intramuscularly. Depending on the dosage and individual metabolism, the effects can last anywhere from 3 to 6 hours or longer.

The legal status of MXE varies from country to country and can change over time. In some regions, it is classified as a controlled substance; in others, it remains legal or in a legal grey area. Researchers and users must stay informed about their jurisdiction's current laws and regulations regarding MXE. Its legality can impact its availability and potential consequences for possession or distribution.


MXE's pharmacology is complex and not fully understood, but it primarily acts as an NMDA receptor antagonist. This means that it blocks the activity of these receptors in the brain, leading to the dissociative and anaesthetic effects associated with MXE use. It also affects other neurotransmitter systems, including serotonin and dopamine, which can contribute to its mood-altering effects.

MXE's unique pharmacological profile has interested researchers in its potential therapeutic applications, particularly in treating various psychiatric disorders.


MXE's chemical structure is characterized by a methoxy group (CH3O-) attached to the nitrogen atom in the cyclohexylamine ring. This substitution is responsible for its distinct properties and effects. The compound's chemical name is 2-(3-methoxyphenyl)-2-(methylamino)cyclohexanone, and its molecular formula is C15H21NO2.

MXE is synthesized through a multi-step process involving various chemical reactions. It falls within the broader category of research chemicals, substances synthesized for scientific and research purposes.

The Methoxetamine Trip

The "trip" on Methoxetamine is often described as unique and profound. Users typically experience a range of sensory and cognitive alterations, which can be exciting and disorienting. Here is a general overview of what a Methoxetamine trip may entail:

  1. Onset: After consumption, the effects of MXE usually begin to manifest within 15-30 minutes, although the start can vary depending on the method of administration and individual factors.
  2. Dissociation: One of the most prominent effects is the sensation of dissociation, where users feel detached from their bodies and the external world. This can lead to feelings of floating or being outside of one's physical self.
  3. Altered Perception: Perception of reality becomes distorted, changing how users perceive their surroundings. Colours may become more vibrant, and sounds may be amplified or distorted.
  4. Euphoria: Many users feel joy and well-being during the trip. This can manifest as intense pleasure and happiness.
  5. Hallucinations: At higher doses, MXE can induce hallucinations. These can be visual, auditory, or even tactile. Users may see vivid and surreal images or hear sounds that aren't present.
  6. Impaired Coordination: MXE can impair motor skills and coordination, making it difficult to move or perform tasks that require fine motor control.
  7. Duration: The effects of MXE can last for several hours, with the peak occurring around 2-3 hours after ingestion. The comedown phase may lead to residual impacts, including feelings of introspection and contemplation.
  8. Afterglow: Some users report a sense of clarity and well-being in the days following a Methoxetamine trip, often referred to as an "afterglow."

It's crucial to approach the Methoxetamine experience with caution and respect. Due to its dissociative and hallucinogenic nature, it can be disorienting and overwhelming for some individuals. As with any psychoactive substance, proper harm reduction practices and responsible use are essential to minimize potential risks.


Methoxetamine is a fascinating and enigmatic compound that offers users a distinctive and often profound altered state of consciousness. Its history, effects, dosage guidelines, legal status, pharmacology, chemistry, and the nature of the trip it provides all contribute to its appeal among researchers and those seeking unique psychoactive experiences. However, it is essential to approach MXE with caution, respect, and a thorough understanding of its potential risks and benefits. Stay informed about the legal status in your area and prioritize safety and responsible use when considering Methoxetamine as an option for research or personal exploration.


What is Methoxetamine (MXE)?

Methoxetamine (MXE) is a dissociative anesthetic and a research chemical that belongs to the arylcyclohexylamine class. It is renowned for its hallucinogenic and dissociative effects.

Is Methoxetamine (MXE) legal?

The legal status of MXE varies by country and region. It has been banned in many places due to its potential for misuse. It's essential to check the current laws and regulations in your area.

How is MXE typically consumed?

MXE is often ingested orally or snorted as a powder. It can also be administered intramuscularly, though this method is less common.

What are the effects of Methoxetamine (MXE)?

MXE can induce a range of effects, including dissociation from one's body and surroundings, altered perception, hallucinations, and a sense of euphoria. The intensity and duration of these effects can vary from person to person.

Are there risks associated with using MXE?

Yes, MXE can be risky. It may lead to physical and psychological harm, addiction, and adverse reactions. Using it in excessive amounts can be dangerous and lead to health issues.

Is Methoxetamine (MXE) addictive?

MXE has the potential for psychological addiction, and some users have reported cravings for the drug. It's important to use it responsibly and be aware of the potential for dependence.

What are the potential side effects of using MXE?

Common side effects of MXE can include dizziness, nausea, confusion, hallucinations, and changes in perception. More severe side effects may include anxiety, paranoia, and disorientation.

Can MXE interact with other drugs or medications?

Yes, MXE can interact with various drugs and medications. It's essential to be cautious and consult a healthcare professional if you are taking other substances or medications.

Is it safe to drive or operate heavy machinery while under the influence of MXE?

No, it is not safe to drive or operate heavy machinery while under the influence of MXE. It impairs coordination and judgment, making it dangerous to engage in activities that require concentration and motor skills.

How long do the effects of MXE typically last?

The duration of MXE effects can vary, but they often last around 3 to 6 hours. Some residual effects or altered perceptions may persist for a longer time.

Can MXE be used for therapeutic purposes?

MXE is not approved for therapeutic use, and its safety and efficacy for medical purposes have not been established. It is primarily considered a recreational drug and a research chemical.

Is it possible to overdose on MXE?

Yes, it is possible to overdose on MXE, which can lead to severe health complications and, in extreme cases, be life-threatening. It's essential to use this substance responsibly and in moderation.

Is there any treatment for MXE addiction or abuse?

Yes, there are treatment options available for individuals struggling with MXE addiction or abuse. These may include counseling, therapy, and support groups.

What should I do if I or someone I know is experiencing adverse effects from MXE?

If you or someone you know is experiencing negative effects from MXE, it is important to seek medical help immediately. Call emergency services or visit the nearest healthcare facility.

Please remember that using Methoxetamine (MXE) can be risky, and it is crucial to make informed and responsible choices regarding its use. This FAQ is for informational purposes only and is not a substitute for professional medical or legal advice.

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