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Product Name: 5-MeO-DMT
IUPAC Name: 2-(5-Methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
Other Names: MXE; 3-MeO-2'-oxo-PCE
Cas Number: 1239943-76-0
Molecular Formula: C15H21NO2
Molar Mass: 247.33 g/mol
Effect: Psychedelics
Purity of the substance: 99.9%
Physical properties: Crystalline powder
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Table of Contents

5-MeO-DMT, short for 5-Methoxy-N,N-Dimethyltryptamine, is a naturally occurring psychoactive compound found in various plants and the venom of certain toads, such as the Colorado River toad (Incilius alvarius). It belongs to the tryptamine class of compounds and shares structural similarities with other powerful psychedelics like DMT (N,N-Dimethyltryptamine) and psilocybin (found in magic mushrooms).

Like DMT, 5-MeO-DMT is renowned for its ability to induce intense and often transformative psychedelic experiences. However, unlike DMT, 5-MeO-DMT is often described as having a more "ego-dissolving" quality, leading to a profound sense of unity and interconnectedness with the universe.

The History of 5-MeO-DMT

The History of 5-MeO-DMT is rich and fascinating. This compound has been used for centuries in various indigenous and shamanic practices. Among these, the use of the Colorado River toad's venom, which contains 5-MeO-DMT, stands out.

Indigenous peoples in the southwestern United States and Mexico have used this substance in their rituals for generations. The practice involves "milking" the venom from the toad and drying it to create a smokable powder. When inhaled, this powder induces powerful psychedelic experiences that are deeply spiritual.

In contemporary times, 5-MeO-DMT has gained popularity in the Western World, particularly among those interested in exploring altered states of consciousness. It has been the subject of scientific research, with studies examining its potential therapeutic applications, such as treating mental health conditions like depression and anxiety.

Effects of 5-MeO-DMT

The effects of 5-MeO-DMT are known for their intensity and brevity. When administered, whether through smoking the toad venom or synthetic forms, users typically experience a rapid onset of effects, often within seconds. The peak of the experience is profoundly intense but relatively short-lived, lasting only a few minutes.

Common effects of 5-MeO-DMT include:

  1. Ego Dissolution: Users often report a complete dissolution of their sense of self, leading to a feeling of unity with the universe. This can be a profoundly spiritual experience.
  2. Intense Visual and Sensory Distortions: Like other psychedelics, 5-MeO-DMT can induce vivid hallucinations and alterations in sensory perception.
  3. Heightened Emotional States: Users may experience intense emotions, including joy, awe, and sometimes fear or discomfort.
  4. Loss of Time and Space: The boundaries of time and space can become distorted or non-existent during a 5-MeO-DMT experience.
  5. Profound Peace and Bliss: Many users report a deep sense of peace and bliss during and after the experience.

It's important to note that while some individuals have transformative and positive experiences with 5-MeO-DMT, others may find it overwhelming or even terrifying. Set and setting, as well as an experienced guide, can significantly influence the nature of the experience.

Dosage of 5-MeO-DMT

The dosage of 5-MeO-DMT is highly potent, and slight variations can lead to significantly different effects. This compound is typically measured in milligrams (mg), with a standard dosage ranging from 5 to 20 mg when vaporized or smoked. Due to its intense nature, it is strongly advised never to eyeball or guess the dosage.

It is crucial to exercise extreme caution when measuring and administering 5-MeO-DMT. A milligram scale should be used to ensure accurate dosing. Additionally, an experienced and responsible sitter or guide is highly recommended, especially for those new to the substance.

Legal Status of 5-MeO-DMT

The legal status of 5-MeO-DMT varies widely around the World. In some countries, it is classified as a controlled substance, making its possession, sale, or use illegal. In others, it may be unregulated or only legal for specific purposes, such as scientific or religious use.

As of my last knowledge update in September 2021, 5-MeO-DMT was illegal in many countries, including the United States, where it was classified as a Schedule I substance. However, legal statuses can change, so you must check the most up-to-date regulations in your region.

Pharmacology of 5-MeO-DMT

5-MeO-DMT, like other tryptamines, primarily affects the serotonin system in the brain. It acts as a potent agonist at serotonin receptors, particularly the 5-HT1A subtype. This interaction is believed to underlie many of its psychedelic effects, including the dissolution of the ego and the altered perception of reality.

Chemistry of 5-MeO-DMT

The chemical structure of 5-MeO-DMT is closely related to that of serotonin, a neurotransmitter with a crucial role in regulating mood, sleep, and various physiological functions. 5-MeO-DMT is a synthetic compound, and its molecular formula is C13H18N2O. It belongs to a class of chemicals known as tryptamines.

The 5-MeO-DMT Trip

The 5-MeO-DMT "trip" refers to the period of intense psychedelic effects experienced after administration. This trip typically begins within seconds of inhaling the vaporized substance and reaches its peak within a few minutes. As mentioned earlier, the experience includes ego dissolution, intense visuals, and profound emotions.

While the trip itself is relatively short, lasting only about 10-20 minutes, many users describe it as one of the most profound and meaningful experiences of their lives. It can be challenging to put into words, often described as ineffable, and may have a lasting impact on one's perspective and overall well-being.


5-MeO-DMT is a powerful psychedelic compound with a rich history of traditional use and increasing interest in modern research. Its ability to induce intense and often transformative experiences makes it a subject of great fascination and, in some cases, controversy. As with any potent psychoactive substance, it should be approached with caution and respect for its effects.


1. What is 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT)?

5-Methoxy-N,N-Dimethyltryptamine, commonly known as 5-MeO-DMT, is a powerful and naturally occurring psychedelic substance found in certain plants and the secretions of the Colorado River toad. It is known for inducing intense, short-lasting psychedelic experiences.

2. What are the street names for 5-MeO-DMT?

5-MeO-DMT is known by various street names, including "The God Molecule" and "Toad Medicine," reflecting its use in spiritual and shamanic practices.

3. What are the effects of 5-MeO-DMT?

5-MeO-DMT is known for inducing intense and often ineffable psychedelic experiences. Effects can include a sense of ego dissolution, unity with the universe, and profound spiritual insights. The duration of the experience is typically very short, lasting only a few minutes.

4. Is 5-MeO-DMT legal?

The legal status of 5-MeO-DMT varies by country and region. In some places, it is considered a controlled substance, while in others, it may not be explicitly regulated. It's crucial to research and understand the legal status in your area before acquiring or using 5-MeO-DMT.

5. How is 5-MeO-DMT typically consumed?

5-MeO-DMT is commonly smoked or vaporized to achieve its effects. The dosage is critical, as the substance is potent, and even a small amount can lead to intense experiences. It is usually administered in a ceremonial or controlled setting.

6. What are the potential risks and side effects of 5-MeO-DMT?

While 5-MeO-DMT is generally considered physically safe, it can induce extremely powerful and overwhelming experiences. Users may encounter psychological and emotional challenges, including intense fear and anxiety. It is crucial to use this substance in a supportive and safe environment with an experienced guide, if possible.

7. Is 5-MeO-DMT safe to use?

The safety of using 5-MeO-DMT depends on various factors, including the individual's physical and mental health, the dose, and the setting. Due to the intensity of the experience, it is often recommended for experienced users or individuals seeking profound spiritual insights. Caution and careful preparation are essential.

8. Can 5-MeO-DMT be used for therapeutic purposes?

Some researchers and therapists are exploring the potential therapeutic applications of 5-MeO-DMT, particularly for conditions like depression, anxiety, and addiction. However, its use in a therapeutic context is still in its early stages of investigation and should only be conducted under the guidance of qualified professionals.

9. How long do the effects of 5-MeO-DMT last?

The effects of 5-MeO-DMT are remarkably brief, typically lasting only a few minutes, with the peak experience occurring within the first minute. Afterward, users may return to their baseline state relatively quickly. Despite the brevity, the experiences can be extremely profound and transformative.

10. Can 5-MeO-DMT be addictive?

There is limited evidence to suggest that 5-MeO-DMT is physically addictive. However, like other powerful psychedelics, it is not typically associated with substance dependence. Psychological addiction is a concern for some individuals, emphasizing the importance of using it responsibly and sparingly.

11. Are there any known drug interactions with 5-MeO-DMT?

Due to the limited research on 5-MeO-DMT, there is a lack of information regarding specific drug interactions. However, combining it with other substances can be risky and unpredictable. It is advisable to avoid combining 5-MeO-DMT with other drugs or medications.

12. Can 5-MeO-DMT cause long-term psychological effects?

The long-term psychological effects of 5-MeO-DMT are not well understood and warrant further research. Some users report enduring positive changes in their lives, such as improved mental well-being and a sense of spiritual growth. However, it may also trigger challenging psychological experiences in some individuals.

13. Where can I find more information about 5-MeO-DMT?

For more information about 5-MeO-DMT, it is recommended to consult scientific literature, reputable online sources, and educational resources. Due to the intense nature of this substance, consider seeking guidance from experienced users, shamans, or professionals if you are interested in exploring its use.

14. Where to get 5-MeO-DMT?

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