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Product Name: AM-2201
IUPAC Name: 1-[(5-Fluoropentyl)-1H-indol-3-yl]-(naphthalen-1-yl)methanone
Other Names: 1-(5-fluoropentyl)-3-(1-naphthoyl)indole
Cas Number: 335161-24-5
Molecular Formula: C24H22FNO
Molar Mass: 359.44 g/mol
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents


In the realm of synthetic compounds that mimic the effects of natural substances, AM-2201 holds a noteworthy place. This synthetic cannabinoid has gained attention due to its association with psychoactive effects similar to those of natural cannabinoids found in the cannabis plant. With its history, effects, dosage, legal status, pharmacology, chemistry, and experience, AM-2201 presents a complex and intriguing subject of study.

The History

Alexandros Makriyannis first synthesized AM-2201 in the 2000s as part of research into cannabinoid receptors. It was initially developed as a tool for studying the endocannabinoid system, which plays a crucial role in regulating various physiological processes. However, its effects on the endocannabinoid system were found to be potent, leading to its emergence as a recreational drug.


The effects of AM-2201 can be similar to those of natural cannabis, although often more intense due to its synthetic nature and high potency. Users have reported sensations of relaxation, euphoria, altered perception, and heightened sensory experiences. However, it's important to note that the effects can include negative outcomes such as anxiety, paranoia, rapid heartbeat, and hallucinations. These adverse effects can be particularly pronounced at higher doses.


Determining the right dosage of AM-2201 is complex and risky due to the lack of standardized guidelines and the potency of the compound. Because it's much stronger than natural cannabinoids, even small amounts can lead to strong effects. Users are at risk of consuming more than intended, which can result in severe negative reactions. Due to the potential for harm, discussing dosage specifics isn't responsible or safe.

Legal Status

The legal status of AM-2201 is a critical aspect to consider. As of my last knowledge update in September 2021, many countries have regulated or banned the compound due to its potential for misuse and adverse health effects. The legality can vary widely, even within a single country. Always prioritize staying informed about the laws in your area and adhere to them to avoid legal repercussions.


AM-2201 exerts its effects by binding to the cannabinoid receptors in the brain, primarily CB1 and CB2 receptors. These receptors are part of the endocannabinoid system, which regulates pain, mood, appetite, and other physiological processes. By interacting with these receptors, AM-2201 can trigger a range of desirable and undesirable effects.


From a chemical standpoint, AM-2201 is classified as a synthetic cannabinoid. Its chemical structure is carefully designed to mimic the structure of natural cannabinoids found in the cannabis plant. This allows it to interact with the same receptors in the brain, producing similar effects. The synthesis of AM-2201 involves complex processes, often requiring specialized equipment and knowledge.

The AM-2201 Trip

Experiences with AM-2201 can vary widely from person to person, depending on factors such as dosage, individual tolerance, and the setting in which it is consumed. Users have reported euphoric sensations, altered perception of time, intensified sensory experiences, and relaxation. However, the trip can quickly turn negative, leading to anxiety, paranoia, and hallucinations. The unpredictable nature of AM-2201's effects makes it a risky substance to experiment with.


AM-2201, as a synthetic cannabinoid, is a testament to the ingenuity of chemical synthesis and its impact on the human body. While initially developed for scientific purposes, its recreational use has raised significant concerns due to its unpredictable effects and potential risks. The legality, pharmacology, and chemistry of AM-2201 all contribute to the complex web of understanding surrounding this compound. However, it's crucial to remember that using substances like AM-2201 can have serious legal and health consequences, and responsible decision-making should always be the top priority. If you or someone you know is struggling with substance misuse, seeking professional help is strongly recommended.


1. What is AM-2201?

AM-2201 is a synthetic cannabinoid compound that falls within the class of research chemicals known as synthetic cannabinoids. Initially developed for research purposes, it lacks approved medical or recreational applications and is frequently employed as a research tool for investigating the endocannabinoid system.

2. Is AM-2201 legal?

The legal status of AM-2201 varies by country and region. In many places, it is considered illegal due to its recreational use, and its safety profile is poorly understood. Researchers should verify the specific laws and regulations in their jurisdiction before engaging with AM-2201.

3. How is AM-2201 typically used?

AM-2201 is primarily employed in laboratory settings for research objectives. It should not be consumed by humans, and its effects on the human body remain poorly comprehended. It should not be used recreationally.

4. What are the potential effects of AM-2201?

Although the effects of AM-2201 are not well-documented, some researchers have reported that it can elicit cannabinoid-like effects in experiments, including altered perception, relaxation, and mood changes. However, these effects can be unpredictable and potentially harmful.

5. Is AM-2201 safe?

Concerns exist regarding the safety of AM-2201. As a synthetic cannabinoid, it can be highly potent and may induce severe adverse effects, such as anxiety, paranoia, hallucinations, and physical symptoms. It is crucial to handle it with extreme caution, use appropriate safety equipment when working with it, and strictly adhere to laboratory safety protocols.

6. Can AM-2201 be used as a recreational drug?

Using AM-2201 as a recreational drug is strongly discouraged. Its effects are not well-understood, and it is known to have a high potential for harm. It is not intended for human consumption and should only be used for legitimate scientific research purposes.

7. How should AM-2201 be stored?

AM-2201 should be stored in a cool, dry, and dark place, away from direct sunlight and moisture. It should be kept in a secure and well-labeled container to prevent accidental exposure. Additionally, access should be restricted to authorized personnel only.

8. Are there any health risks associated with AM-2201 exposure?

Exposure to AM-2201 can be hazardous to health, and it may cause various adverse effects, both acute and chronic. It is essential to take necessary precautions and use personal protective equipment when handling the substance to minimize the risks.

9. Is AM-2201 still used in research?

Research on synthetic cannabinoids has evolved, with many newer compounds available for scientific investigation. While AM-2201 has been used in research, it is not as commonly studied as it once was due to safety concerns and the emergence of alternative compounds.

10. Where can I find more information about AM-2201?

For specific information on the availability, legal status, and potential uses of AM-2201 in your area, you should contact local authorities or consult relevant scientific literature and databases. Researchers should also be aware of any updates to regulations and safety guidelines in their region.

11. Where to get AM-2201?

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