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Product Name: 5-MeO-DiPT
IUPAC Name: [2-(5-Methoxy-1H-indol-3-yl)ethyl]bis(propan-2-yl)amine
Other Names: 5-MeO-DiPT, Foxy Methoxy, Foxy
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  1. Introduction
  2. Chemistry
  3. Pharmacology
  4. Dosage
  5. Subjective Effects
  6. Physical Effects
  7. Visual Effects
  8. Cognitive Effects
  9. Auditory Effects
  10. Toxicity and Harm Potential
  11. FAQ
  12. Legal Status


5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT), also known as Foxy and Foxy Methoxy, belongs to the tryptamine class of psychedelics. Its psychedelic effects have been documented since its first human trials in 1975 by Alexander Shulgin.


The first human trials of 5-MeO-DiPT were conducted by Alexander Shulgin in 1975, with further research leading to the publication of a paper detailing its synthesis and psychopharmacology in 1981. A comprehensive overview of its synthesis and human use was included in Shulgin's 1997 book TiHKAL ("Tryptamines I Have Known And Loved").


Anecdotal reports describe the effects of 5-MeO-DiPT as highly stimulating and mildly entactogenic, with limited psychedelic visual distortions. Users often report intense physical and tactile sensations, leading to heightened libido and sexual pleasure. However, higher dosages can induce an unpleasant body load. Some users also note sound distortion, similar to the effects observed with the related compound, DiPT.

Pharmacology and Toxicity

Despite its usage, little is known about the pharmacological properties, metabolism, and toxicity of 5-MeO-DiPT. It remains relatively obscure with a limited history of human use. Sold primarily as a research chemical online, caution and harm reduction practices are highly advised for those considering its use.


Molecular Structure

5-MeO-DiPT, also known as 5-methoxy-N,N-diisopropyltryptamine, belongs to the synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a common core structure consisting of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. In the case of 5-MeO-DiPT, it is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group (CH3O−), and it contains two isopropyl chains bound to the terminal amine RN of its tryptamine backbone (DiPT).

5-MeO-DiPT is the N-substituted diisopropyl homolog of 5-MeO-MiPT.


Mechanism of Action

The purported hallucinogenic and entheogenic effects of 5-MeO-DiPT are primarily thought to result from 5-HT2A receptor agonism, although additional mechanisms of action such as monoamine oxidase inhibition (MAOI) may also be involved. It's noteworthy that the strongest receptor binding affinity for 5-MeO-DiPT is at the 5-HT1A receptor. However, the precise role of these interactions and how they contribute to the psychedelic experience remain elusive.


  • Threshold: 3 mg
  • Light: 3 - 10 mg
  • Common: 10 - 15 mg
  • Strong: 15 - 20 mg
  • Heavy: 20 mg and above

Subjective Effects


The effects listed below are based on anecdotal user reports and the personal analyses of contributors to the Subjective Effect Index (SEI). As such, they should be approached with a healthy degree of skepticism.

It's important to note that these effects may not occur predictably or reliably, although higher doses are more likely to induce the full spectrum of effects. Additionally, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death.

Physical Effects


  • Spontaneous Physical Sensations: Users may experience spontaneous physical sensations.
  • Bodily Pressures: Sensations of bodily pressure can occur.
  • Nausea: Nausea is a common side effect.
  • Abnormal Heartbeat: (citation needed)
  • Increased Heart Rate: (citation needed)
  • Increased Blood Pressure: (citation needed)
  • Headaches: (citation needed)
  • Stomach Bloating: At higher dosages, 5-MeO-DiPT can induce severe stomach bloating in susceptible individuals. This effect can be partially to fully mitigated through the use of antacids.
  • Vasoconstriction
  • Diarrhea
  • Dehydration
  • Pupil Dilation

Visual Effects

  • Enhancements:
    • Colour Enhancement
    • Pattern Recognition Enhancement
    • Visual Acuity Enhancement
  • Distortions:
    • Drifting (Melting, Breathing, Morphing, and Flowing)
    • Colour Shifting
    • Depth Perception Distortions
    • Perspective Distortions
    • Symmetrical Texture Repetition
    • Tracers
    • Afterimages
    • Brightness Alteration
    • Diffraction
  • Geometry
  • Hallucinatory States:
    • Transformations
    • Internal Hallucination (Autonomous Entities; Settings, Sceneries, and Landscapes; Perspective Hallucinations and Scenarios and Plots)

Cognitive Effects

Conceptual Thinking

  • Users may experience enhanced conceptual thinking.

Cognitive Euphoria

  • Cognitive euphoria, characterized by feelings of happiness and well-being, can occur.


  • Delusional thinking may manifest during the experience.

Emotion Enhancement

  • Emotional experiences may be intensified.

Immersion Enhancement

  • Users may feel a heightened sense of immersion in their surroundings or activities.

Increased Music Appreciation

  • Music may be perceived as more enjoyable or profound.

Memory Suppression

  • The compound may lead to suppression of memory recall.

Ego Death

  • Ego dissolution or ego death, characterized by a loss of the sense of self, can occur.

Novelty Enhancement

  • Perception of novelty in familiar experiences may be heightened.

Personal Bias Suppression

  • Users may experience a reduction in personal biases or prejudices.

Thought Loops

  • Thought loops, where thoughts become repetitive and circular, may occur.

Time Distortion

  • Time perception may become distorted, leading to a sense of time dilation or compression.

Unity and Interconnectedness

  • Users may feel a sense of unity or interconnectedness with the universe or others.

Auditory Effects


  • Auditory experiences may be enhanced, with sounds perceived as richer or more vibrant.


  • Auditory distortions, such as changes in pitch or tone, may occur.


  • Users may experience auditory hallucinations, hearing sounds that are not actually present.

Toxicity and Harm Potential

The long-term health effects of recreational 5-MeO-DiPT use have not been studied in any scientific context, and the exact toxic dose is unknown. This is due to its classification as a research chemical with minimal human usage history. Neurotoxic effects have been studied in rats.

Anecdotal reports suggest that trying 5-MeO-DiPT by itself at low to moderate doses or using it sparingly is not associated with negative health effects. However, caution is advised, as individual reactions can vary, and comprehensive research should always precede consumption, especially when combining substances.

It is strongly recommended to practice harm reduction measures when using this compound.


Excessive doses of 5-MeO-DiPT have been associated with several adverse effects, including:

  • Nausea
  • Vomiting
  • Agitation
  • Decreased blood pressure
  • Pupil dilation
  • Increased heart rate
  • Hallucinations In severe cases, rhabdomyolysis and renal failure have occurred, leading to fatalities.

Tolerance and Addiction Potential

5-MeO-DiPT, like other serotonergic psychedelics, is not considered habit-forming. However, tolerance to its effects develops rapidly after ingestion. It takes approximately three days for tolerance to reduce to half and seven days to return to baseline in the absence of further consumption. Additionally, 5-MeO-DiPT exhibits cross-tolerance with other psychedelics, meaning their effects may be diminished after its use.

Dangerous Interactions

Combining 5-MeO-DiPT with certain substances can be dangerous and even life-threatening. Some known dangerous interactions include:

  • 2C-T-X
  • 2C-X
  • Cannabis
  • DOx
  • MDMA
  • Mescaline
  • NBOMe
  • Amphetamines
  • Cocaine
  • DXM
  • Tramadol
  • aMT
  • MAOIs
  • PCP

Legal Status

The legal status of 5-MeO-DiPT varies by country:

  • Brazil: Illegal
  • China: Illegal
  • Denmark: Illegal
  • Germany: Controlled substance
  • Greece: Illegal
  • Japan: Illegal
  • Latvia: Illegal
  • New Zealand: Class C controlled drug
  • Singapore: Illegal
  • Sweden: Illegal
  • Switzerland: Controlled substance
  • United Kingdom: Class A drug
  • United States: Schedule I controlled substance


What is 5-MeO-DiPT?

5-MeO-DiPT, also known as Foxy or Foxy Methoxy, is a synthetic indole alkaloid of the tryptamine class, known for its psychedelic effects.

How does 5-MeO-DiPT affect the body?

5-MeO-DiPT primarily acts as a serotonergic psychedelic, with effects such as stimulation, visual and auditory enhancements, cognitive euphoria, and ego dissolution.

What are the potential risks of using 5-MeO-DiPT?

Excessive doses of 5-MeO-DiPT can lead to adverse effects such as nausea, vomiting, agitation, decreased blood pressure, hallucinations, and even fatalities in severe cases. Additionally, combining it with certain substances can be dangerous.

Is 5-MeO-DiPT addictive?

5-MeO-DiPT is not considered habit-forming, but tolerance to its effects develops rapidly, and it presents cross-tolerance with other psychedelics.

How should 5-MeO-DiPT be used safely?

It is recommended to practice harm reduction measures when using 5-MeO-DiPT, such as starting with low doses, avoiding combining it with other substances, and ensuring a safe and comfortable setting.

What is the legal status of 5-MeO-DiPT?

The legal status of 5-MeO-DiPT varies by country, with it being illegal or controlled in many jurisdictions, including the United States, United Kingdom, and several European countries.

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