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Table of Contents

1. Introduction

   • Overview of 4-HO-DPT
   • Synthesis and Origin
   • Relationship to Other Compounds

2. Chemistry of 4-HO-DPT

   • Structure and Composition
   • Comparison to Other Compounds

3. Pharmacology of 4-HO-DPT

   • Mechanism of Action
   • Dosage Guidelines

4. Subjective Effects of 4-HO-DPT

   • Disclaimer
   • Comparison to Other Tryptamines
   • Physical Effects
   • Visual Effects
   • Cognitive Effects
   • Auditory Effects

5. Toxicity and Harm Potential

   • Lack of Scientific Study
   • Anecdotal Evidence
   • Harm Reduction Practices
   • Tolerance and Addiction Potential
   • Dangerous Interactions
   • Legal Status

Introduction

4-HO-DPT, also recognized as 4-hydroxy-N,N-dipropyltryptamine, and occasionally referred to as Procin, emerges as a notable psychedelic substance within the tryptamine class. Alexander Shulgin, a prominent chemist, synthesized 4-HO-DPT and meticulously documented its properties in his renowned book TiHKAL (Tryptamines I Have Known and Loved). This compound represents the 4-hydroxyl analog of DPT.

Origins and Synthesis

Alexander Shulgin's synthesis of 4-HO-DPT marked a significant milestone in the exploration of tryptamine derivatives. Its synthesis process has been detailed in TiHKAL, adding to the comprehensive understanding of psychedelic compounds.

Usage and Accessibility

Today, 4-HO-DPT finds its place either in recreational circles or as an entheogenic compound, valued for its profound effects on consciousness. Typically, enthusiasts acquire 4-HO-DPT through online research chemical vendors. However, due to the intricacy of its synthesis, this compound remains relatively uncommon even within the realm of substituted tryptamines. Its history of human usage is scant, reflecting its novelty and limited exposure among psychedelic users.

Structure and Composition

4-HO-DPT, also known as 4-hydroxy-N,N-dipropyltryptamine, belongs to the synthetic indole molecules within the tryptamine class. Tryptamines share a fundamental structure characterized by a bicyclic indole heterocycle linked at R3 to an amino group through an ethyl side chain. At R4 of its indole heterocycle, 4-HO-DPT features a hydroxyl functional group (OH−). Additionally, it contains two propyl chains attached to the terminal amine RN of its tryptamine backbone (DPT).

Relationship to Other Compounds

4-HO-DPT serves as the 4-hydroxy analog of 4-AcO-DPT and represents the N-substituted dipropyl homolog of psilocin (4-HO-DMT).

Pharmacology of 4-HO-DPT

Mechanism of Action

Similar to most psychedelic tryptamines, 4-HO-DPT is believed to primarily function as a 5-HT2A partial agonist. Its psychedelic effects are attributed to its binding efficacy at the 5-HT2A receptors. However, the precise mechanisms underlying these interactions and how they contribute to the psychedelic experience remain incompletely understood.

Dosage Guidelines for 4-HO-DPT

• Threshold: 20 mg
• Light: 40 - 60 mg
• Common: 60 - 90 mg
• Strong: 90 - 130 mg
• Heavy: 130 mg and above

Subjective Effects of 4-HO-DPT

Disclaimer

The effects outlined below draw from the Subjective Effect Index (SEI), which relies on anecdotal user reports and analyses by PsychonautWiki contributors. Readers should approach these effects with caution and skepticism. It's important to note that individual experiences may vary, and higher doses may lead to a wider range of effects, including adverse reactions such as addiction, severe injury, or even death.

Comparison to Other Tryptamines

In comparison to other tryptamines like 4-AcO-DMT and 4-HO-DMT, 4-HO-DPT shares similarities in its visual, cognitive, and physical effects. However, users report that it feels somewhat less natural and slightly more synthetic. Notably, it lacks the highly uncomfortable physical side effects associated with its structural relative, DPT, making its experience more akin to that of generic or classical substituted tryptamines such as psilocin.

Physical Effects

• Spontaneous physical sensations
• Bodily control enhancement
• Increased heart rate
• Nausea
• Sedation
• Pupil dilation
• Tactile enhancement
• Mouth numbing
• Physical euphoria
• Muscle relaxation

Visual Effects

• Enhancements
• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement
• Suppressions
• Visual acuity suppression
• Distortions
• Drifting (melting, breathing, morphing, and flowing)
• Colour shifting
• Depth perception distortions
• Perspective distortions
• Symmetrical texture repetition
• Tracers
• After images
• Brightness alteration
• Diffraction
• Scenery slicing
• Geometry
• Hallucinatory states
• Internal hallucination

Cognitive Effects

• Analysis enhancement
• Conceptual thinking
• Cognitive euphoria
• Delusion
• Emotion enhancement
• Immersion enhancement
• Increased music appreciation
• Memory suppression
• Ego death
• Novelty enhancement
• Personal bias suppression
• Thought acceleration
• Thought loops
• Time distortion
• Unity and interconnectedness
• Laughter
• Language suppression
• Mindfulness

Auditory Effects

• Enhancements
• Distortions
• Hallucinations

Toxicity and Harm Potential of 4-HO-DPT

Lack of Scientific Study

The toxicity and long-term health effects associated with recreational use of 4-HO-DPT have not been extensively studied in scientific contexts. The exact toxic dose remains unknown due to the limited history of human usage of 4-HO-DPT, which is primarily considered a research chemical.

Anecdotal Evidence

Anecdotal evidence from individuals within the psychonaut community who have experimented with 4-HO-DPT suggests that there are generally no negative health effects when the drug is used alone at low to moderate doses and sparingly. However, it's important to emphasize that nothing can be completely guaranteed, and independent research should always be conducted to ensure the safety of combining 4-HO-DPT with other substances.

Harm Reduction Practices

It is strongly recommended that individuals practice harm reduction techniques when using 4-HO-DPT or any other psychoactive substance to minimize risks and adverse effects associated with its consumption.

Tolerance and Addiction Potential

4-HO-DPT is not considered habit-forming, and the desire to use it may decrease with regular consumption, similar to most psychedelics. Tolerance to the effects of 4-HO-DPT develops rapidly after ingestion. It takes approximately three days for the tolerance to decrease by half and about seven days to return to baseline in the absence of further consumption. Additionally, 4-HO-DPT exhibits cross-tolerance with other psychedelics, meaning that the consumption of 4-HO-DPT reduces the effects of other psychedelics.

Dangerous Interactions

Warning: Combining psychoactive substances can lead to dangerous and life-threatening outcomes. The following list outlines some known dangerous interactions, but it may not encompass all possible scenarios. Independent research should always be conducted to verify the safety of combining substances.

• Lithium: Combining lithium, commonly prescribed for bipolar disorder, with psychedelics like 4-HO-DPT significantly increases the risk of psychosis and seizures.

• Cannabis: Cannabis can have unpredictable and strong effects when combined with 4-HO-DPT, potentially leading to adverse psychological reactions such as anxiety, paranoia, panic attacks, and psychosis.

• Stimulants: Stimulants like amphetamine, cocaine, or methylphenidate may increase the risk of anxiety, paranoia, panic attacks, and thought loops when combined with 4-HO-DPT. This combination may also elevate the risk of mania and psychosis.

• Tramadol: Tramadol lowers the seizure threshold, and when combined with psychedelics like 4-HO-DPT, it may trigger seizures in susceptible individuals.

Legal Status

The legal status of 4-HO-DPT varies by country:

• Germany: Controlled under the NpSG (New Psychoactive Substances Act) since July 18, 2019.

• Sweden: Classified as a "dangerous substance" requiring a special permit for purchase or sale.

• Switzerland: Not controlled under specific regulations.

• United Kingdom: Classified as a Class A drug.

• United States: Unscheduled but may be prosecuted under the Federal Analogue Act as an analogue of psilocin.

FAQ (Frequently Asked Questions)

Q1: Has 4-HO-DPT been extensively studied for toxicity and long-term health effects?

A1: No, there is limited scientific study on the toxicity and long-term health effects of recreational 4-HO-DPT use. The exact toxic dose remains unknown due to its classification as a research chemical.

Q2: Are there reported negative health effects associated with 4-HO-DPT use?

A2: Anecdotal evidence from the psychonaut community suggests that there are generally no negative health effects when using 4-HO-DPT alone at low to moderate doses. However, caution and independent research are advised.

Q3: Is 4-HO-DPT habit-forming?

A3: No, 4-HO-DPT is not habit-forming, and the desire to use it may decrease with regular consumption, aligning with the typical self-regulating nature of psychedelics.

Q4: How quickly does tolerance develop, and does 4-HO-DPT exhibit cross-tolerance with other psychedelics?

A4: Tolerance to 4-HO-DPT develops almost immediately after ingestion. It takes about 3 days for tolerance to reduce by half and 7 days to return to baseline. Cross-tolerance with other psychedelics is observed.

Q5: What are the dangerous interactions associated with 4-HO-DPT?

A5: Combining 4-HO-DPT with substances like lithium, cannabis, stimulants, and tramadol can lead to dangerous outcomes. Independent research is crucial to ensuring safety.

Q6: What is the legal status of 4-HO-DPT in different countries?

A6: The legal status varies; for example, it is unscheduled in the United States but controlled in Germany under the NpSG. Users should be aware of and adhere to local regulations.