Buy STS-135 for sale online from USA vendor

Table of Contents

1. Chemistry
2. Pharmacology
3. Subjective Effects
4. Physical Effects
5. Cognitive Effects
6. Toxicity and Harm Potential
7. Tolerance and Addiction Potential
8. Dangerous Interactions
9. Legal Status

Exploring STS-135: A Synthetic Cannabinoid

Understanding STS-135

STS-135, scientifically known as N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide or 5F-APICA, belongs to the class of synthetic cannabinoids. These compounds act as potent agonists for the cannabinoid receptors, eliciting subjective effects reminiscent of cannabis consumption. However, STS-135 is characterized by a short duration of action and a pronounced emphasis on intense physical sensations.

Pharmacological Insights

Despite its popularity, there exists a scarcity of comprehensive data regarding the pharmacology of STS-135 within the scientific literature. This lack of information poses challenges in fully understanding its mechanisms of action and potential risks. Nevertheless, STS-135 remains accessible for purchase as a grey area research chemical through online vendors.

Administration and Effects

Traditionally, cannabinoids are often smoked or vaporized to achieve rapid onset of effects and quick offset. However, STS-135 exhibits oral activity when dissolved in lipids, leading to a prolonged duration of action. While insoluble in water, it readily dissolves in ethanol and lipids, facilitating its administration via various routes.

Risk Factors and Safety Concerns

It's imperative to acknowledge that synthetic cannabinoids, including STS-135, pose significant risks compared to natural cannabis. Chronic abuse of these substances has been linked to adverse effects, including fatalities and heightened toxicity. Consequently, prolonged usage or excessive doses of STS-135 are strongly discouraged due to the potential for severe side effects and health complications.

In summary, STS-135 represents a synthetic cannabinoid with distinct pharmacological properties, administration routes, and associated risks. While it shares similarities with cannabis, caution must be exercised due to the limited understanding of its effects and potential dangers.

Unraveling STS-135: A Synthetic Cannabinoid

Chemistry of STS-135

STS-135, scientifically termed N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, belongs to the class of synthetic cannabinoids. Its chemical structure comprises a substituted indole group. Specifically, the indole moiety is substituted at R1 with a fluoropentyl chain, a feature shared with compounds like 5F-PB-22, THJ-2201, and 5F-AKB48. Furthermore, the indole is substituted at R3 with a carboxamide group, with the terminal amine group of this carboxamide being N-substituted with an adamantane group—a unique structural motif composed of four fused cyclohexane rings, forming what is termed a diamondoid. STS-135 can be considered an analog of 5F-AKB48, where the core indazole structure is substituted with an indole base.

Pharmacological Insights

Although formal studies regarding STS-135 are limited, structural analysis suggests similarities in its binding profile to that of other cannabinoids, including Δ9-THC. In vitro studies have indicated that STS-135 acts as a potent agonist for cannabinoid receptors, exhibiting an EC50 of 51 nM for human CB2 receptors and 13 nM for human CB1 receptors. Experimental evidence in rats has shown that STS-135 induces bradycardia and hypothermia at doses ranging from 1 to 10 mg/kg, further suggesting cannabinoid-like activity. However, the precise mechanisms underlying these interactions and their role in producing the subjective experience associated with cannabinoids remain poorly understood.

Subjective Effects and Safety Considerations

Disclaimer: The subjective effects described below are derived from the Subjective Effect Index (SEI), based on anecdotal user reports and personal analyses from contributors to PsychonautWiki. It's crucial to approach these effects with caution and skepticism, as individual responses may vary, and higher doses can increase the likelihood of adverse effects, including addiction, severe injury, or death.

While STS-135 may produce effects akin to those of natural cannabinoids, its usage carries inherent risks. The subjective effects experienced by individuals consuming STS-135 may not follow a predictable pattern, with higher doses amplifying the spectrum of effects. Adverse effects become more probable with increased dosage, necessitating caution in consumption.

In summary, STS-135 represents a synthetic cannabinoid with a complex chemical structure and pharmacological profile. Despite its potential for producing cannabinoid-like effects, the limited understanding of its mechanisms and associated risks underscores the importance of cautious usage and further research into its properties.

Unraveling the Chemistry of STS-135

Chemical Composition

STS-135, formally known as N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, belongs to the synthetic cannabinoid family. Its structure encompasses a substituted indole group, with specific substitutions at key positions. At R1, there is a fluoropentyl chain, a feature shared with compounds like 5F-PB-22, THJ-2201, and 5F-AKB48. Additionally, the indole is substituted at R3 with a carboxamide group. Notably, this carboxamide group is N-substituted at its terminal amine group with an adamantane group, comprising four fused cyclohexane rings, forming a diamondoid structure. STS-135 can be regarded as an analog of 5F-AKB48, with the core indazole structure replaced by an indole base.

Insights into Pharmacology

Binding Profile

Formal studies regarding STS-135 are limited; however, structural analysis suggests similarities in its binding profile to other cannabinoids, notably resembling properties of Δ9-THC. In vitro experiments have indicated that STS-135 acts as a potent cannabinoid receptor agonist, exhibiting an EC50 of 51 nM for human CB2 receptors and 13 nM for human CB1 receptors. Furthermore, experiments in rats have demonstrated its ability to induce bradycardia and hypothermia at doses ranging from 1 to 10 mg/kg, suggesting cannabinoid-like activity. Nevertheless, the precise mechanisms underlying these interactions and their correlation with the subjective "high" remain elusive.

Exploring Subjective Effects

Disclaimer and Effects

It is pertinent to note that the subjective effects described below are based on anecdotal reports from users and the Subjective Effect Index (SEI), which relies on personal analyses by contributors to platforms like PsychonautWiki. Hence, these effects should be interpreted with caution. Additionally, the occurrence of these effects may not be consistent or predictable, with higher doses typically associated with a broader spectrum of effects. Moreover, it's crucial to acknowledge the increasing likelihood of adverse effects, including addiction, severe injury, or even fatality, at higher doses.

Understanding Dosage Guidelines

• Threshold: < 0.5 mg
• Light: 0.5 - 1.5 mg
• Common: 1.5 - 2 mg
• Strong: 2 - 4 mg
• Heavy: 4 mg +

Exploring Physical Effects of STS-135

Spontaneous Tactile Sensations

The "body high" induced by STS-135 is often characterized by sharp, uncomfortable, electric tingling sensations that encompass the entire body post-ingestion. These sensations escalate rapidly upon onset, reaching their peak intensity before promptly dissipating.

Motor Control Impairment

STS-135 tends to induce partial to moderate suppression of motor control, a effect that escalates with dosage. However, it typically does not lead to complete inability to walk or perform basic movements.

Appetite Enhancement

Similar to many other cannabinoids, STS-135 triggers an increase in appetite, colloquially referred to as "the munchies" in American and UK culture. Clinical studies and survey data have affirmed that cannabinoids, including synthetic variants, enhance food enjoyment and stimulate interest in food. This effect is attributed to the activation of cannabinoid receptors responsible for regulating food intake in the hypothalamus.

Pain Relief

Clinical evidence suggests that cannabinoids, through agonism of CB1 and CB2 receptors, offer pain relief. This analgesic effect extends to synthetic cannabinoid receptor agonists like STS-135.

Perception Alterations

STS-135 may induce perceptions of bodily heaviness or lightness, accompanied by changes in perception of gravity.

Dehydration and Vasodilation

Commonly known as "cotton mouth," dehydration is a notable side effect associated with STS-135. Additionally, vasodilation, characterized by the widening of blood vessels, can occur.

Examining Cognitive Effects of STS-135

Anxiety and Paranoia

STS-135 exhibits a propensity to induce feelings of anxiety, particularly when compared to other cannabinoids. Individuals prone to anxiety should exercise caution when using this compound.

Emotion Enhancement

Users may experience heightened emotional responses while under the influence of STS-135.

Thought Connectivity and Deceleration

This substance can enhance thought connectivity, facilitating novel associations between ideas. Additionally, it may induce thought deceleration, slowing down the stream of consciousness.

Conceptual Thinking and Mindfulness

STS-135 might promote conceptual thinking, enabling users to explore abstract ideas. It may also induce a state of mindfulness, enhancing present-moment awareness.

Analysis Suppression

Users may experience suppression of analytical thinking while under the influence of STS-135.

Dream Suppression

Prolonged usage of synthetic cannabinoids like STS-135 may suppress dreaming activity during sleep.

Psychosis Risk

There is evidence to suggest that prolonged use of synthetic cannabinoids could elevate the risk of psychosis, especially in individuals predisposed to psychotic illnesses such as schizophrenia, either through personal or family history.

Increased Music Appreciation

STS-135 may enhance the appreciation of music among users.

Auditory Effects

Enhancements and Distortions

Auditory experiences under the influence of STS-135 may include enhancements in perception as well as distortions in auditory stimuli.

Evaluating Toxicity and Harm Potential of STS-135

Lack of Scientific Study

The toxicity and long-term health effects of recreational STS-135 use remain largely unexplored within scientific research. Due to its limited history of human usage, the exact toxic dosage remains unknown. Anecdotal evidence from users within the community suggests that low to moderate doses of STS-135 used sparingly typically do not lead to negative health effects. However, overdosing may result in physical discomfort such as heart palpitations, vertigo, and sedation, often accompanied by heightened anxiety or sleepiness.

Mental Health Considerations

Individuals with severe pre-existing mental conditions are often advised against ingesting STS-135 due to its potential to exacerbate current states of mind and emotions. Prolonged usage of synthetic cannabinoids, akin to THC, may increase susceptibility to mental illness and psychosis, particularly among vulnerable individuals with risk factors such as a personal or family history of schizophrenia.

Harm Reduction and Precautions

Given that synthetic cannabinoids are active in the milligram range, it is crucial to exercise proper precautions when dosing to avoid adverse experiences. Adopting harm reduction practices is strongly recommended to mitigate potential risks associated with STS-135 usage.

Understanding Tolerance and Addiction Potential

As with other synthetic cannabinoids, chronic use of STS-135 can lead to moderate addiction potential and psychological dependence among certain users. Tolerance to its effects typically develops with prolonged and repeated use, necessitating increasingly larger doses to achieve the desired effects. Moreover, STS-135 induces cross-tolerance with all cannabinoids, meaning that consumption of STS-135 may reduce the effectiveness of other cannabinoids.

Tolerance Reduction

After cessation of use, it takes approximately 3 to 7 days for tolerance to decrease by half and 1 to 2 weeks to return to baseline levels. However, individuals who have developed addiction may experience cravings and withdrawal effects upon discontinuation of usage.

Identifying Dangerous Interactions

Warning: Combining STS-135 with certain substances can lead to dangerous and potentially life-threatening interactions. Stimulants such as amphetamines and cocaine can heighten anxiety levels and increase the risk of negative experiences when combined with STS-135. Always conduct thorough research to ensure the safety of combining multiple substances.

Legal Status

STS-135 was developed as an attempt to circumvent drug prohibition laws regulating synthetic cannabinoids. Consequently, it remains legal in many parts of the world, although legal implications may arise under certain circumstances, such as possession under analogue laws or with intent to sell or consume.

Specific Legal Status:

• China: Controlled substance since October 2015.
• Germany: Controlled under Narcotics Act since December 13, 2014.
• Latvia: Schedule I controlled substance.
• Switzerland: Named as a controlled substance under Verzeichnis E.
• United Kingdom: Class B controlled substance since December 14, 2016.

Frequently Asked Questions (FAQ)

1. What is STS-135?

STS-135, also known as N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, is a synthetic cannabinoid drug with properties similar to those of cannabis.

2. What are the common doses of STS-135?

• Threshold: < 0.5 mg
• Light: 0.5 - 1.5 mg
• Common: 1.5 - 2 mg
• Strong: 2 - 4 mg
• Heavy: 4 mg +

3. What are the physical effects of STS-135?

Physical effects of STS-135 may include spontaneous tactile sensations, motor control loss, appetite enhancement, pain relief, perception alterations, dehydration, and vasodilation.

4. What are the cognitive effects of STS-135?

Cognitive effects may include anxiety, paranoia, emotion enhancement, thought connectivity, thought deceleration, conceptual thinking, mindfulness, analysis suppression, dream suppression, and increased music appreciation.

5. Is STS-135 toxic?

The long-term health effects of STS-135 have not been extensively studied. While low to moderate doses may not lead to negative health effects, overdosing can cause physical discomfort and heightened anxiety.

6. Can STS-135 lead to addiction?

Chronic use of STS-135 can be moderately addictive and may result in psychological dependence. Tolerance to its effects develops with prolonged use, requiring larger doses to achieve the same effects.

7. Are there any dangerous interactions with STS-135?

Combining STS-135 with certain substances, such as stimulants like amphetamines and cocaine, can lead to dangerous interactions. Always research potential interactions before combining substances.

8. What is the legal status of STS-135?

The legal status of STS-135 varies by country. It may be legal in some places but controlled or prohibited in others. It's essential to be aware of local laws and regulations regarding its possession and use.