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Product Name: 4-HO-DET
IUPAC Name: 3-(2-diethylaminoethyl)-1H-indol-4-ol
Other Names: 4-HO-DET, Ethocin, CZ-74
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents

  1. Introduction

    • 1.1 Overview
    • 1.2 Chemical Composition
  2. Discovery and Origin

    • 2.1 Founding Researchers
    • 2.2 Human Clinical Trials
  3. Usage and Availability

    • 3.1 Popularity Trends
    • 3.2 Online Research Chemical Vendors
  4. Chemistry

    • 4.1 Molecular Structure
    • 4.2 Relationship to Other Compounds
  5. Pharmacology

    • 5.1 Serotonergic Psychedelic Action
  6. Dosage

    • 6.1 Threshold
    • 6.2 Light
    • 6.3 Common
    • 6.4 Strong
    • 6.5 Heavy
  7. Subjective Effects

    • 7.1 Visual and Sensory Experiences
    • 7.2 Cognitive Effects
    • 7.3 Auditory Effects
  8. Toxicity and Harm Potential

    • 8.1 Lack of Scientific Studies
    • 8.2 Harm Reduction Practices
    • 8.3 Tolerance and Addiction Potential
    • 8.4 Dangerous Interactions
  9. Legal Status

    • 9.1 Germany
    • 9.2 Sweden
    • 9.3 Switzerland
    • 9.4 United Kingdom
    • 9.5 United States
  10. Conclusion


4-Hydroxy-N,N-diethyltryptamine, commonly referred to as 4-HO-DET, CZ-74, or Ethocin, stands as a lesser-known synthetic psychedelic within the tryptamine chemical class. This compound shares a close structural and functional resemblance to psilocin (4-HO-DMT), the principal psychoactive component found in magic mushrooms. The effects induced by 4-HO-DET are reminiscent of psilocin, encompassing psychedelic experiences that affect cognition, visuals, and bodily sensations.

Discovery and Origin

First identified in the late 1950s by pioneers Albert Hofmann and Franz Troxler during their exploration of psychedelic compounds related to psilocybin and psilocin, 4-HO-DET entered the scientific realm. This investigation aimed to uncover substances structurally and chemically connected to the active components derived from magic mushrooms.

The compound, along with its phosphoryloxy-analog 4-PO-DET, underwent human clinical trials in the 1960s under the supervision of German researchers Hanscarl Leuner and G. Baer, adding to the early understanding of its properties and potential applications.

Limited Usage and Documentation

Despite its early discovery and initial research, 4-HO-DET has maintained a low profile within the realm of psychedelics. Human usage documentation remains scarce, with most psychedelic enthusiasts gravitating towards more conventional substances like psilocybin and psilocin, commonly found in psilocybin mushrooms. In recent times, compounds like 4-AcO-DMT have also gained preference among users.

Today, 4-HO-DET is seldom encountered as a recreational substance or an entheogen. Its limited prevalence on the streets is noteworthy, as it is primarily obtained through online research chemical vendors. The lack of widespread usage documentation highlights the compound's niche status in the broader landscape of psychedelics.

In conclusion, 4-Hydroxy-N,N-diethyltryptamine remains an intriguing but relatively obscure member of the psychedelic family, with its unique features and subtle variations continuing to capture the interest of a select group of enthusiasts.

Chemistry of 4-HO-DET

4-HO-DET, or 4-hydroxy-N,N-diethyltryptamine, belongs to the synthetic indole alkaloid category within the tryptamine chemical class. Tryptamines, characterized by a bicyclic indole heterocycle connected at R3 to an amino group via an ethyl side chain, serve as the core structure for this class of molecules. 4-HO-DET, in particular, features a hydroxyl functional group (OH−) at R4 of its indole heterocycle and two ethyl chains bound to the terminal amine RN of its tryptamine backbone (DET).

Structural Relationships

This compound holds significance as the lower homolog of 4-AcO-DET, being the N-substituted diethyl homolog of 4-HO-DMT (psilocin) and the 4-hydroxy analog of DET. The intricacies of its molecular structure contribute to its unique properties and the range of effects it produces.

Pharmacology of 4-HO-DET

Serotonergic Psychedelic Action

In the realm of pharmacology, 4-HO-DET, like its structurally related tryptamines, primarily functions as a 5-HT2A partial agonist. This interaction with the serotonin receptor is central to the compound's psychedelic effects. The intricate mechanisms through which these interactions lead to the psychedelic experience are still under scientific scrutiny, and further research is needed to fully elucidate the complexities of 4-HO-DET's pharmacological actions. The quest for understanding these interactions remains a focal point in the ongoing exploration of psychedelic compounds and their effects on the human mind and body.

Dosage of 4-HO-DET

Understanding the appropriate dosage of 4-HO-DET is crucial for achieving desired effects while minimizing potential risks. This synthetic tryptamine compound, similar to others in its class, elicits a range of effects dependent on the quantity administered.

Dosage Guidelines

  • Threshold: 5 mg
  • Light: 10 - 15 mg
  • Common: 20 - 30 mg
  • Strong: 30 - 45 mg
  • Heavy: 45 mg and above

Subjective Effects

Note: The following subjective effects section is a work in progress and may contain incomplete or inaccurate information. Contributions to expand or correct this section are welcomed.

In comparison to other isolated synthetic tryptamine compounds such as 4-AcO-DMT and 4-HO-DMT, 4-HO-DET has been reported to share similarities in visual, cognitive, and physical effects. Notably, it exhibits a slightly extended duration, diminished bodily effects, and visuals described as more "synthetic" or "algorithmic" in style.


It is essential to approach the effects outlined below with a degree of skepticism, as they are derived from the Subjective Effect Index (SEI). The SEI is based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. It is worth noting that the occurrence of these effects may not be predictable or reliable, though higher doses are more likely to induce the full spectrum of effects.

Furthermore, it is crucial to be aware that adverse effects become increasingly likely with higher doses. These adverse effects may include but are not limited to addiction, severe injury, or, in extreme cases, death. Caution and responsible usage are paramount when experimenting with any psychoactive substances.

Physical Effects of 4-HO-DET

Understanding the physical effects of 4-HO-DET is essential for individuals exploring the compound. These effects encompass various sensations and changes in bodily functions, contributing to the overall psychedelic experience.

Spontaneous Physical Sensations

  • Tactile Enhancement: Heightened sensitivity to touch.
  • Stimulation: Increased energy and alertness.
  • Temperature Regulation Suppression: Potential decrease in the ability to regulate body temperature.
  • Bodily Control Enhancement: Improved control over bodily movements.
  • Increased Heart Rate: Elevated heart rate, a common physiological response.
  • Excessive Yawning: Pronounced yawning, a unique aspect among psilocin and related tryptamines.
  • Watery Eyes: Tear production, often occurring alongside excessive yawning.
  • Frequent Urination: Increased frequency of urination.
  • Muscle Contractions: Sporadic muscle contractions.
  • Olfactory Hallucination: Distorted or heightened sense of smell.
  • Pupil Dilation: Enlargement of the pupils.
  • Runny Nose: Nasal discharge.

Visual Effects

  • Enhancements: Heightened visual perception.
  • Colour Enhancement: Intensification of colors.
  • Pattern Recognition Enhancement: Improved ability to perceive patterns.
  • Visual Acuity Enhancement: Increased visual clarity.
  • Distortions: Altered visual perceptions.
  • Drifting (Melting, Breathing, Morphing, and Flowing): Objects appearing to move or warp.
  • Tracers: Persistent trails following moving objects.
  • Colour Tinting: Alteration of perceived colors.
  • Colour Shifting: Changes in the color spectrum.
  • Depth Perception Distortions: Altered perception of depth.
  • Perspective Distortions: Changes in visual perspective.
  • Symmetrical Texture Repetition: Repeated patterns with symmetry.
  • Geometry: Complex and abstract visual patterns, similar to psilocin and ayahuasca.
  • Hallucinatory States: Perception of machinescapes and transformative experiences.
  • Internal Hallucination: Autonomous entities, settings, sceneries, landscapes, and hallucinatory scenarios.
  • External Hallucination: Perception of entities, settings, sceneries, landscapes, and hallucinatory scenarios.

Cognitive Effects

  • Analysis Enhancement: Improved analytical thinking.
  • Conceptual Thinking: Enhanced ability for abstract thought.
  • Immersion Enhancement: Heightened engagement in experiences.
  • Increased Music Appreciation: Enhanced appreciation for auditory stimuli.
  • Increased Sense of Humor: Heightened humor perception.
  • Laughter Fits: Uncontrollable fits of laughter.
  • Memory Suppression: Impaired recall of memories.
  • Ego Death: Transcendence of the self.
  • Novelty Enhancement: Increased appreciation for novelty.
  • Personal Bias Suppression: Diminished subjective biases.
  • Thought Acceleration: Increased thought speed.
  • Thought Connectivity: Enhanced connection between thoughts.
  • Thought Loops: Repetitive thought patterns.
  • Time Distortion: Altered perception of time.
  • Wakefulness: Increased state of alertness.

Auditory Effects

  • Enhancements: Heightened auditory perception.
  • Distortions: Altered auditory perceptions.
  • Hallucinations: Perception of nonexistent sounds.

It is important to approach the effects mentioned with caution, acknowledging that individual responses may vary. Responsible usage and understanding personal tolerance levels are crucial when engaging with 4-HO-DET.

Toxicity and Harm Potential of 4-HO-DET

Exploring the toxicity and harm potential of 4-HO-DET is crucial for individuals considering its recreational use. While the compound falls within the realm of research chemicals, limited scientific studies on its long-term health effects exist due to its relatively recent emergence and minimal human usage history.

Lack of Scientific Study

The toxicity and long-term health effects of recreational 4-HO-DET use have not been extensively studied within a scientific context. The exact toxic dose remains unknown, adding to the uncertainty surrounding its safety profile. Anecdotal evidence from the psychonaut community suggests that trying the substance alone at low to moderate doses and using it sparingly may not result in negative health effects. However, caution is emphasized, and independent research should precede any consumption, especially when combining with other substances.

Harm Reduction Practices

It is strongly recommended to employ harm reduction practices when using 4-HO-DET. This includes thorough research on the substance, understanding its potential interactions, and ensuring a safe environment for consumption. Harm reduction aims to minimize risks associated with substance use and promotes responsible experimentation.

Tolerance and Addiction Potential

4-HO-DET is reported not to be habit-forming, and in some cases, the desire to use it can decrease with continued use. Tolerance to the effects develops almost immediately after ingestion. It takes about 3 days for the tolerance to halve and 7 days to return to baseline in the absence of further consumption. Notably, 4-HO-DET induces cross-tolerance with all psychedelics, reducing their effects.

Dangerous Interactions


Combining psychoactive substances can result in dangerous and even life-threatening situations. Known dangerous interactions include:

  • Lithium: Combining with lithium, commonly prescribed for bipolar disorder, may significantly increase the risk of psychosis and seizures.
  • Cannabis: The synergy between 4-HO-DET and cannabis can lead to unexpected and intense psychological reactions. Caution is advised to minimize the risk of anxiety, paranoia, panic attacks, and psychosis.
  • Stimulants: The use of stimulants like amphetamine, cocaine, or methylphenidate with 4-HO-DET can heighten the risk of anxiety, paranoia, panic attacks, and thought loops. It may also elevate the risk of mania and psychosis.
  • Tramadol: The combination of tramadol, known to lower the seizure threshold, with psychedelics may increase the risk of seizures.

Independent research is essential to ensure the safety of combining two or more substances.

Legal Status


4-HO-DET is controlled under Anlage I BtMG (Narcotics Act, Schedule I). Its manufacture, possession, import, export, purchase, sale, procurement, or dispensing without a license is illegal.


Classified as a health hazard, 4-HO-DET is illegal to sell or possess under the Act on the Prohibition of Certain Goods Dangerous to Health.


4-HO-DET is a controlled substance named under Verzeichnis E.

United Kingdom:

Classified as a Class A drug under the tryptamine catch-all clause.

United States:

Unscheduled, but may be considered an analogue of psilocin (4-HO-DMT), a Schedule I drug. Sale for human consumption or illicit non-medical/industrial use could be prosecuted under the Federal Analogue Act.


  1. Is 4-HO-DET habit-forming?

    • 4-HO-DET is not habit-forming, and the desire to use it may decrease with use.
  2. What is the recommended harm reduction approach?

    • Harm reduction practices are strongly recommended when using 4-HO-DET to ensure safety.
  3. How quickly does tolerance build after ingestion?

    • Tolerance to 4-HO-DET builds almost immediately after ingestion, with a gradual reduction over 3 to 7 days.
  4. Are there dangerous interactions with other substances?

    • Yes, potential dangerous interactions include combinations with lithium, cannabis, stimulants, and tramadol.
  5. What is the legal status of 4-HO-DET in the United States?

    • 4-HO-DET is unscheduled in the United States but may be considered an analogue of psilocin, subject to the Federal Analogue Act.
  6. How is 4-HO-DET controlled in Germany?

    • In Germany, 4-HO-DET is controlled under Anlage I BtMG, making it illegal without a license.
  7. Can 4-HO-DET be legally possessed or sold in Sweden?

    • No, 4-HO-DET is classified as a health hazard, making it illegal to sell or possess in Sweden.
  8. What is the chemical relationship between 4-HO-DET and other tryptamines?

    • 4-HO-DET is the lower homolog of 4-AcO-DET, the N-substituted diethyl homolog of 4-HO-DMT (psilocin), and the 4-hydroxy analog of DET.
  9. How are the visual effects of 4-HO-DET described?

    • Visual effects include enhancements, distortions, and hallucinations, with a "synthetic" feel, resembling those of psilocin and ayahuasca.
  10. Is there any documented research on the long-term health effects of 4-HO-DET?

    • No, the toxicity and long-term health effects of 4-HO-DET have not been scientifically studied due to its limited history of human usage. Independent research is recommended.

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