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3-Hydroxyeticyclidine, often known as 3-HO-PCE, is a new dissociative drug that has gained interest as a study molecule in recent years. This arylcyclohexylamine molecule causes significant dissociative, hallucinogenic, and euphoric effects, making it a desirable chemical for those trying to alter their mental state. However, despite the drug's increasing popularity, there is a shortage of information on it, making it difficult for users to comprehend its possible hazards and side effects. This page aims to offer a complete overview of 3-HO-PCE, including its effects, hazards, and current knowledge.
What is 3-Hydroxyeticyclidine (3-HO-PCE)?
3-HO-PCE is a unique synthesized dissociable molecule that belongs to the chemical class arylcyclohexylamine. It shares a structural similarity with its near analogue 3-HO-PCP, which has been demonstrated to have an affinity for the -opioid receptor in animal models. In contrast to 3-HO-PCP, 3-HO-PCE had no antecedent in the scientific literature before its introduction to the market for research chemicals in the 2010s.
Effects of 3-Hydroxyeticyclidine (3-HO-PCE)
The effects of 3-HO-PCE are dose-dependent; however, it is typically regarded as a solid dissociative, hallucinogenic, and euphoric drug. It is supposed to cause an altered state of consciousness characterized by a sensation of detachment from the body and the physical world. Some users claim dramatic visual and aural hallucinations, while others report extreme exhilaration and heightened perception. However, these effects might be unexpected and vary considerably from person to person.
Risks of 3-Hydroxyeticyclidine (3-HO-PCE)
3-HO-PCE, like all other research compounds, is connected with multiple dangers and adverse consequences. As with any drug, the likelihood of adverse effects increases with increasing dosages. Anxiety, paranoia, disorientation, and psychological side effects are among the potential hazards of 3-HO-PCE. In addition, bodily injury is dangerous, such as convulsions, high blood pressure and heart rate, and other cardiovascular side effects.
Affinity for the μ-Opioid Receptor
Given its structural similarity to 3-HO-PCP, which has been found to exhibit affinity for the -opioid receptor in animal models, one of the earliest discussions over 3-HO-PCE centred on whether it had a substantial affinity for this receptor. Whether 3-HO-PCE causes any of its hypothesized opioid effects in people is the topic of ongoing debate. Still, if it does, it may represent distinct hazards compared to other dissociatives, significantly when reduced.
To prepare the content, the following materials were used:
- FDA Substance Registration System
- Hazardous Substances Data Bank. National Library of Medicine. 28 August 2008. Retrieved 22 August 2014. 3,4-Methylenedioxymethamphetamine
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