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Product Name: 4-HO-MPT
IUPAC Name: 3-[2-(Methylpropylamino)ethyl]-4-indolol
Other Names: 4-HO-MPT, Meprocin
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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  • 4-HO-MPT for sale online from USA vendor

Table of Contents


  • 1.1 Overview of 4-HO-MPT
  • 1.2 Synthesis and Description by Alexander Shulgin


  • 2.1 Structural Characteristics of 4-HO-MPT
  • 2.2 Tryptamine Class and Core Structure

Dosage Guidelines and Pharmacology

  • 3.1 Dosage Ranges
  • 3.2 Pharmacological Insights

Subjective Effects

  • 4.1 Disclaimer on Reported Effects
  • 4.2 Variable and Unpredictable Nature
  • 4.3 Potential Risks and Adverse Effects

Physical and Visual Effects

  • 5.1 Physical Sensations and Responses
  • 5.2 Visual Enhancements and Distortions
  • 5.3 Hallucinatory States

Cognitive and Auditory Effects

  • 6.1 Cognitive Dimensions
  • 6.2 Auditory Dimensions

Toxicity and Harm Potential

  • 7.1 Limited Research and Lack of Scientific Context
  • 7.2 Anecdotal Evidence and Cautionary Measures
  • 7.3 Tolerance and Addiction Potential
  • 7.4 Dangerous Interactions
  • 7.5 Legal Status

Overview of a Novel Synthetic Psychedelic Substance

4-Hydroxy-N-methyl-N-propyltryptamine, commonly known as 4-HO-MPT or Meprocin, is a distinctive synthetic psychedelic substance belonging to the tryptamine chemical class. This compound induces psychedelic effects upon administration and is closely related in structure to 4-HO-DMT (Psilocin) and other potent hallucinogenic tryptamines.

Limited Understanding of Pharmacology, Metabolism, and Toxicity

Despite its intriguing properties, there exists scant data concerning the pharmacological characteristics, metabolism, and toxicity of 4-HO-MPT. Since 2016, it has been available for purchase online as a research chemical, emphasizing the novelty and limited research surrounding its effects. Notably, 4-HO-MPT was synthesized and documented by Alexander Shulgin in his 1994 book "TiHKAL."

Unraveling the Chemistry Behind 4-HO-MPT

Structure and Composition

The chemical structure of 4-HO-MPT, or 4-hydroxy-N,N-methylpropyltryptamine, reveals its identity as a synthetic indole molecule within the tryptamine class. Tryptamines share a foundational structure featuring a bicyclic indole heterocycle linked at R3 to an amino group via an ethyl side chain. In the case of 4-HO-MPT, a hydroxyl functional group (OH−) is situated at R4 of its indole heterocycle, contributing to its unique properties. Additionally, the compound contains a propyl and ethyl chain bound to the terminal amine RN of its tryptamine backbone (MPT). Understanding the intricate chemistry of 4-HO-MPT lays the groundwork for further exploration into its effects and potential applications.

Understanding Dosage Ranges

When experimenting with 4-Hydroxy-N-methyl-N-propyltryptamine (4-HO-MPT), it is crucial to adhere to specific dosage guidelines to achieve desired effects while minimizing potential risks.

Dosage Recommendations

  • Threshold: 5 mg
  • Light: 10 - 20 mg
  • Common: 20 - 30 mg
  • Strong: 30 - 50 mg
  • Heavy: 50 mg and above

Adhering to these dosage ranges is essential for users to tailor their experience according to their desired intensity while maintaining safety.

Unveiling the Pharmacology of 4-HO-MPT

Psychedelic Ties to the Tryptamine Class

4-HO-MPT belongs to the tryptamine class of chemical compounds and stands as a higher homologue of psilocin, a naturally occurring substituted tryptamine. Additionally, it serves as the 4-hydroxyl analog of MPT, adding to its distinctive pharmacological profile.

Mechanism of Action

Similar to many psychedelic tryptamines, 4-HO-MPT is believed to primarily act as a 5-HT2A partial agonist. The psychedelic effects associated with its consumption are thought to result from the compound's binding efficacy at the 5-HT2A receptors. However, the precise role of these interactions and how they contribute to the overall psychedelic experience remains elusive, underscoring the need for further research into the pharmacology of 4-HO-MPT.

Subjective Effects of 4-HO-MPT

Disclaimer on Reported Effects

Before delving into the subjective effects of 4-Hydroxy-N-methyl-N-propyltryptamine (4-HO-MPT), it is essential to acknowledge the source of information. The effects outlined below are based on the Subjective Effect Index (SEI), a compilation of anecdotal user reports and analyses by contributors to PsychonautWiki. Readers should approach these findings with a healthy degree of skepticism, recognizing the subjective nature of individual experiences.

Variable and Unpredictable Nature

It is crucial to emphasize that the reported effects of 4-HO-MPT may not occur predictably or reliably for every user. Individual responses can vary significantly, and factors such as dosage, set, and setting play pivotal roles in shaping the subjective experience. Higher doses, while more likely to induce the full spectrum of effects, also increase the likelihood of adverse reactions.

Potential Risks and Adverse Effects

While exploring the subjective effects of 4-HO-MPT, it is imperative to consider the associated risks. Higher doses, in particular, may lead to adverse outcomes, including but not limited to addiction, severe injury, or even death. Users are urged to exercise caution, adhere to recommended dosage guidelines, and be aware of the potential consequences of higher doses. This acknowledgment underscores the importance of responsible use and the need for further research to fully understand the intricacies of 4-HO-MPT's effects.

Physical and Visual Effects of 4-HO-MPT

Physical Sensations and Responses

4-Hydroxy-N-methyl-N-propyltryptamine (4-HO-MPT) elicits various physical effects, contributing to the overall psychedelic experience. It is essential to note that individual responses may vary.

Spontaneous Physical Sensations

Users of 4-HO-MPT may encounter spontaneous physical sensations, adding a tactile dimension to their experience. These sensations can range from subtle tingling to more pronounced feelings of warmth or pressure.

Increased Heart Rate

One common physiological response to 4-HO-MPT is an increase in heart rate. Users may notice heightened cardiac activity, which is a typical reaction associated with many psychedelics.


Nausea is another potential physical effect linked to 4-HO-MPT consumption. While not universal, some users may experience mild to moderate nausea during the onset or peak of the psychedelic experience.

Pupil Dilation

Pupil dilation is a hallmark sign of psychedelic influence, and 4-HO-MPT is no exception. Users may observe dilated pupils, a visual manifestation of the compound's impact on the autonomic nervous system.

Visual Enhancements and Distortions

4-HO-MPT induces a range of visual effects, enhancing perception and introducing distortions to the visual field.


  • Colour Enhancement: Colors may appear more vivid and intense.
  • Pattern Recognition Enhancement: Users may notice heightened recognition and appreciation of patterns.
  • Visual Acuity Enhancement: Improved clarity and sharpness of vision may occur.


  • Drifting (Melting, Breathing, Morphing, and Flowing): Static objects may exhibit fluid-like movements.
  • Colour Shifting: Colors may change subtly or dramatically.
  • Depth Perception Distortions: Perceived distances and dimensions may alter.
  • Perspective Distortions: Users might experience shifts in visual perspective.
  • Symmetrical Texture Repetition: Patterns may repeat symmetrically.
  • Tracers: Trails or echoes may follow moving objects.
  • After Images: Lingering images may persist after the removal of a visual stimulus.
  • Brightness Alteration: Changes in overall brightness perception.
  • Diffraction: Light may diffract, creating visual spectra.
  • Geometry: Geometric patterns may emerge in the visual field.

Hallucinatory States

The psychedelic experience with 4-HO-MPT extends to hallucinatory states, involving profound transformations and internal visualizations.

  • Transformations: Objects may undergo significant changes.
  • Internal Hallucination: Users may encounter autonomous entities, intricate settings, sceneries, landscapes, perspective hallucinations, and even scenarios and plots.

These visual effects contribute to the unique and immersive nature of the 4-HO-MPT experience, though individual responses may differ.

Cognitive Dimensions of 4-HO-MPT

Understanding the cognitive effects of 4-Hydroxy-N-methyl-N-propyltryptamine (4-HO-MPT) is crucial for comprehending its impact on mental processes during a psychedelic experience.

Conceptual Thinking

4-HO-MPT may influence conceptual thinking, leading to novel connections and perspectives. Users may experience an expansion of thought patterns and enhanced creativity.

Cognitive Euphoria

The compound has the potential to induce cognitive euphoria, characterized by heightened mental well-being and a positive shift in mood. This effect contributes to the overall emotional experience.


Delusional thinking may occur in some users under the influence of 4-HO-MPT. It is important to approach the experience with awareness and discernment to distinguish between altered perceptions and reality.

Emotion Enhancement

Users may undergo emotion enhancement, intensifying emotional responses to stimuli. This effect can lead to a deeper connection with one's feelings and surroundings.

Immersion Enhancement

4-HO-MPT can enhance the sense of immersion, making users more engaged with their environment and experiences. This effect may contribute to a more profound and immersive psychedelic journey.

Increased Music Appreciation

A notable cognitive effect of 4-HO-MPT is the heightened appreciation of music. Sound may become more vibrant, emotionally resonant, and immersive, enhancing the overall sensory experience.

Memory Suppression

The compound may induce memory suppression, impacting the recall of events during the psychedelic experience. Users should be mindful of potential short-term memory effects.

Ego Death

Ego death, a profound loss of the sense of self, is a potential cognitive effect of 4-HO-MPT. This experience can lead to a transcendent and ego-dissolving state.

Novelty Enhancement

4-HO-MPT has been reported to enhance the perception of novelty, making routine experiences or stimuli feel fresh and unfamiliar.

Personal Bias Suppression

The psychedelic may suppress personal biases, allowing users to perceive situations and ideas with greater objectivity and openness.

Thought Loops

Thought loops, where repetitive thought patterns become momentarily stuck, can occur with 4-HO-MPT. Users may find themselves revisiting the same ideas or concepts.

Time Distortion

Perceptions of time may become distorted, with time feeling either elongated or compressed. This effect contributes to the altered sense of reality during the experience.

Auditory Dimensions

Examining the auditory effects of 4-HO-MPT adds another layer to the psychedelic encounter.

Auditory Enhancements

Sound may be enhanced, becoming more vibrant, rich, and detailed.

Auditory Distortions

Auditory distortions can manifest, altering the perception of pitch, tone, or volume.

Auditory Hallucinations

Transpersonal experiences may involve auditory hallucinations, where users perceive sounds that are not present in their external environment.

Unity and Interconnectedness

A unique cognitive effect of 4-HO-MPT is the potential for experiencing a sense of unity and interconnectedness with the surrounding world and other beings. This transcendent state can foster a deep connection and understanding of the interrelated nature of existence.

Toxicity and Harm Potential of 4-HO-MPT

Limited Research and Lack of Scientific Context

The toxicity and long-term health effects of recreational 4-Hydroxy-N-methyl-N-propyltryptamine (4-HO-MPT) use remain largely unexplored within the realm of scientific investigation. The scarcity of studies on this research chemical, coupled with its minimal history of human usage, makes it challenging to pinpoint the exact toxic dose and evaluate potential health risks associated with its consumption.

Anecdotal Evidence and Cautionary Measures

Anecdotal evidence from individuals within the community who have experimented with 4-HO-MPT suggests that trying the substance at low to moderate doses, used sparingly, does not appear to lead to negative health effects. However, it is essential to approach these accounts with caution, acknowledging the inherent limitations of anecdotal evidence.

It is strongly emphasized that independent research should precede the combination of 4-HO-MPT with other substances to ensure safety. Harm reduction practices are encouraged to minimize potential risks associated with its use.

Tolerance and Addiction Potential

4-HO-MPT is generally considered non-habit-forming, and users may experience a decrease in the desire to use it with regular consumption. Similar to many psychedelics, it is often perceived as self-regulating.

Tolerance to the effects of 4-HO-MPT builds almost immediately after ingestion. It takes approximately 3 days for the tolerance to be reduced by half and 7 days to return to baseline in the absence of further consumption. Importantly, 4-HO-MPT presents cross-tolerance with all psychedelics, diminishing the effects of other substances in this class.

Dangerous Interactions and Cautionary Notes

Warning on Dangerous Interactions

Users are advised to exercise caution and conduct independent research to ensure the safety of combining 4-HO-MPT with other substances. The following list highlights some known dangerous interactions, although it may not cover all possibilities.

  • Lithium: Combining 4-HO-MPT with lithium, commonly prescribed for bipolar disorder, is discouraged due to anecdotal evidence suggesting an increased risk of psychosis and seizures.
  • Cannabis: Users should approach the combination of 4-HO-MPT with cannabis cautiously, as it may result in unexpected and potentiated effects, potentially leading to adverse psychological reactions.
  • Stimulants: Stimulants such as amphetamine, cocaine, or methylphenidate, when combined with 4-HO-MPT, can elevate the risk of anxiety, paranoia, panic attacks, and thought loops.
  • Tramadol: The combination of tramadol and psychedelics may lower the seizure threshold, potentially triggering seizures in susceptible individuals.

Legal Status

International Legal Standing

  • Germany: 4-HO-MPT is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019, with specific legal consequences for production, import, administration, placement on the market, and trading.
  • Switzerland: Not currently controlled under specific classifications, potentially rendering it legal.
  • United Kingdom: Classified as a Class A drug under the tryptamine catch-all clause.
  • United States: Unscheduled, but it may be considered an analogue of psilocin (4-HO-DMT), a Schedule I drug. The sale for human consumption or illicit use could be prosecuted under the Federal Analogue Act.

FAQ (Frequently Asked Questions)

Q1: Is 4-HO-MPT a habit-forming substance?

A1: 4-HO-MPT is generally considered not habit-forming, and users may experience a decrease in the desire to use it with regular consumption.

Q2: What is the potential risk of combining 4-HO-MPT with other substances?

A2: Combining 4-HO-MPT with certain substances may pose risks. Users should conduct independent research to ensure safety, especially considering interactions with lithium, cannabis, stimulants, and tramadol.

Q3: How long does tolerance to 4-HO-MPT last?

A3: Tolerance to 4-HO-MPT builds almost immediately after ingestion. It takes about 3 days for tolerance to be reduced by half and 7 days to return to baseline in the absence of further consumption.

Q4: Are there any reported long-term health effects of 4-HO-MPT use?

A4: The long-term health effects of recreational 4-HO-MPT use have not been scientifically studied. Anecdotal evidence suggests no negative health effects at low to moderate doses, but caution is advised.

Q5: What is the legal status of 4-HO-MPT in different countries?

A5: The legal status varies by country. In the United States, it is unscheduled but may be considered an analogue of psilocin. In the United Kingdom, it is classified as a Class A drug, while in Germany, it is controlled under the NpSG. In Switzerland, it is not currently controlled.

Q6: How should one approach harm reduction when using 4-HO-MPT?

A6: Harm reduction practices are strongly recommended, including responsible dosing, conducting independent research on substance interactions, and being aware of potential risks associated with the psychedelic experience.

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