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Specification
Product Name: 4-AcO-MiPT
IUPAC Name: 3-[2-[Isopropyl(methyl)amino]ethyl]-1H-indol-4-yl] acetate
Other Names: 4-AcO-MiPT, Mipracetin, O-Acetylmiprocin
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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  • 4-AcO-MiPT for sale online from USA vendor

Table of Contents

  1. Overview

    • Introduction
    • Human Pharmacology and Toxicity
    • Chemistry
    • Pharmacology
  2. Subjective Effects

    • Disclaimer
    • Physical Effects
    • Cognitive Effects
    • Auditory, Multi-sensory, and Transpersonal Effects
  3. Dosage Guidelines

    • Threshold Dosage
    • Light Dosage
    • Common Dosage
    • Strong Dosage
    • Heavy Dosage
  4. Toxicity and Harm Potential

    • Lack of Scientific Study
    • Anecdotal Evidence
    • Responsible Use
    • Tolerance and Addiction Potential
    • Dangerous Interactions
    • Legal Status

Introduction

4-Acetoxy-N-methyl-N-isopropyltryptamine, commonly known as 4-AcO-MiPT or mipracetin, is a synthetic psychedelic tryptamine. This compound is the acetylated derivative of 4-HO-MiPT (miprocin) and belongs to the same chemical family as 4-AcO-DMT, 4-AcO-MET, and 4-AcO-DET. These substances are often theorized to function as prodrugs for their hydroxylated counterparts, such as 4-HO-DMT and 4-HO-MET, though ongoing debates question whether they exhibit unique inherent activity[citation needed].

Human Pharmacology and Toxicity

Despite its presence in recreational and entheogenic use, there is limited information regarding the human pharmacology and toxicity of 4-AcO-MiPT. Analytical methods have been developed for its detection[1][2]. Commonly acquired through online research chemical vendors, 4-AcO-MiPT remains relatively uncommon with minimal historical usage.

Chemistry

4-AcO-MiPT, or 4-Acetoxy-N-isopropyl-N-methyltryptamine, is a synthetic indole alkaloid of the tryptamine class. Tryptamines share a core structure consisting of a bicyclic indole heterocycle attached to an amino group via an ethyl side chain. At R4 of its indole heterocycle, 4-AcO-MiPT features an acetoxy (AcO) functional group (CH3COO−), along with isopropyl and methyl chains bound to the terminal amine RN of its tryptamine backbone (MiPT).

4-AcO-MiPT serves as the N-substituted methisopropyl homologue of 4-HO-DMT (psilocin) and is the acetate ester analog of MiPT, as well as the N-substituted methisopropyl analog of 4-AcO-DMT[3].

Pharmacology

As with most psychedelic tryptamines, 4-AcO-MiPT is believed to primarily act as a 5-HT2A partial agonist. The psychedelic effects stem from its binding efficacy at the 5-HT2A receptors. However, the specific mechanisms underlying these interactions and their role in the psychedelic experience remain elusive.

Subjective Effects

Disclaimer: The effects outlined below are based on the Subjective Effect Index (SEI), relying on anecdotal user reports and the analyses of PsychonautWiki contributors. As such, they should be approached with a degree of skepticism.

It is crucial to note that these effects may not occur predictably or reliably, with higher doses being more likely to induce the full spectrum of effects. Additionally, adverse effects, including addiction, severe injury, or death, become more probable at higher doses. Users should exercise caution and be aware of the potential risks associated with the consumption of 4-AcO-MiPT.

Physical Effects

Excessive Yawning

One of the notable physical effects associated with the consumption of 4-AcO-MiPT is excessive yawning. Trippers commonly experience uncontrollable yawning, which is considered a characteristic response to the substance.

Sedation

In terms of physical energy levels, 4-AcO-MiPT is generally regarded as a relaxing, stoning, and mildly sedating compound. Users often report a sense of sedation, accompanied by the aforementioned excessive yawning.

Spontaneous Tactile Sensations

Referred to as the "body high," users describe the tactile sensations induced by 4-AcO-MiPT as pleasurable, warm, soft, and all-encompassing tingling. This sensation is consistently present, gradually intensifying with onset and reaching its peak during the height of the experience.

Pupil Dilation

Pupil dilation is another observable physical effect associated with the consumption of 4-AcO-MiPT, indicating alterations in the autonomic nervous system.

Runny Nose and Watery Eyes

Users may also experience a runny nose and watery eyes as part of the physical effects induced by 4-AcO-MiPT.

Cognitive Effects

Analysis Enhancement

Similar to its counterpart 4-HO-MiPT, 4-AcO-MiPT is reported to induce extremely relaxing, complex, and stoning cognitive effects. This sets it apart from other psychedelics like LSD or 2C-B, which are typically characterized as energetic and stimulating. Analysis enhancement is one of the cognitive effects associated with 4-AcO-MiPT.

Conceptual Thinking

Users often experience enhanced conceptual thinking, contributing to a unique cognitive experience distinct from other commonly used psychedelics.

Delusion

Delusional thinking is another cognitive effect observed in individuals under the influence of 4-AcO-MiPT, highlighting alterations in thought patterns.

Autonomous Voice Communication

Some users report engaging in autonomous voice communication, a phenomenon where individuals perceive communication from an internal or external source.

Déjà Vu

The experience of déjà vu, a feeling of familiarity with situations or events, is reported as a cognitive effect induced by 4-AcO-MiPT.

Emotion Enhancement

Users commonly report heightened emotional experiences, indicating an enhancement of emotional responses during the psychedelic experience.

Enhancement and Suppression Cycles

This phenomenon involves constant waves of highly stimulated and profound thinking alternated with waves of general thought suppression and mental intoxication. These cycles occur in a consistent loop approximately every 20 to 60 minutes.

Immersion Enhancement

4-AcO-MiPT is associated with the enhancement of immersive experiences, where users may feel more deeply connected to their surroundings.

Increased Music Appreciation

A notable cognitive effect is the increased appreciation of music, with users reporting heightened sensitivity to auditory stimuli.

Memory Suppression

The substance induces memory suppression, affecting the recall of events during the period of intoxication.

Ego Death

Ego death, characterized by a dissolution of the sense of self, is reported as a profound cognitive effect associated with 4-AcO-MiPT.

Novelty Enhancement

Users often experience an increased perception of novelty, finding ordinary stimuli to be more intriguing or profound.

Personal Bias Suppression

The psychedelic experience with 4-AcO-MiPT may lead to the suppression of personal biases, allowing users to perceive situations with greater objectivity.

Thought Connectivity

Users report a heightened sense of thought connectivity, with thoughts and ideas flowing more seamlessly and interconnectedly.

Thought Loops

A common cognitive effect includes the occurrence of thought loops, where individuals find themselves repeatedly contemplating the same ideas or concepts.

Time Distortion

Alterations in the perception of time are reported, with users experiencing a distorted sense of time passing.

Wakefulness

Despite its sedative physical effects, 4-AcO-MiPT is noted for promoting wakefulness, allowing users to remain alert and engaged during the psychedelic experience.

Auditory Effects

Auditory Enhancement

Individuals under the influence of 4-AcO-MiPT commonly report auditory enhancement. This involves an intensified perception of sounds, making them more vibrant and noticeable.

Auditory Distortion

Auditory distortion is another auditory effect associated with 4-AcO-MiPT. It involves alterations in the quality or characteristics of sounds, contributing to the overall psychedelic experience.

Auditory Hallucination

Users may experience auditory hallucinations, perceiving sounds that are not present in their external environment. This phenomenon adds an extra layer to the auditory effects induced by 4-AcO-MiPT.

Multi-sensory Effects

Synaesthesia

In its fullest manifestation, synaesthesia is a rare and non-reproducible effect associated with 4-AcO-MiPT. The likelihood of experiencing synaesthesia can increase with higher dosages, but it appears to be more prominent among individuals predisposed to synaesthetic states. Synaesthesia involves the blending or confusion of sensory experiences, such as seeing sounds or tasting colors.

Transpersonal Effects

Spirituality Enhancement

Reported less reliably and impactfully than with substances like psilocybin or 4-AcO-DMT, spirituality enhancement is still noted as a transpersonal effect of 4-AcO-MiPT. Users may experience a heightened sense of spiritual connection or significance during the psychedelic experience.

Existential Self-Realization

Individuals under the influence of 4-AcO-MiPT may undergo existential self-realization, gaining insights into their existence, purpose, or identity.

Unity and Interconnectedness

The sense of unity and interconnectedness is another transpersonal effect associated with 4-AcO-MiPT. Users may feel a profound connection to the universe or a oneness with all things.

It is crucial to acknowledge that these auditory, multi-sensory, and transpersonal effects may occur less reliably and impactfully compared to other psychedelics like psilocybin or 4-AcO-DMT. Additionally, heavier doses of 4-AcO-MiPT may be required to induce these effects. Individuals considering the use of 4-AcO-MiPT should be aware of these potential experiences and approach the substance with caution.

Dosage Guidelines for 4-Acetoxy-N-methyl-N-isopropyltryptamine (4-AcO-MiPT)

Threshold Dosage

5 mg

The threshold dosage for 4-AcO-MiPT is typically reported at 5 mg. At this level, users may begin to perceive subtle effects, marking the onset of the psychedelic experience.

Light Dosage

10 - 15 mg

A light dosage of 4-AcO-MiPT ranges between 10 to 15 mg. Users at this level may experience mild to moderate effects, with a heightened sensory perception and a gentle introduction to the psychedelic experience.

Common Dosage

15 - 20 mg

The common dosage range for 4-AcO-MiPT falls between 15 to 20 mg. At this level, users can expect a more pronounced and immersive psychedelic experience, with enhanced sensory perceptions, cognitive effects, and potential alterations in consciousness.

Strong Dosage

20 - 35 mg

A strong dosage of 4-AcO-MiPT is considered to be within the range of 20 to 35 mg. At this level, users can anticipate intensified and profound effects, including heightened sensory experiences, cognitive distortions, and potentially deeper insights into the self and the surrounding environment.

Heavy Dosage

35 mg +

A heavy dosage of 4-AcO-MiPT is categorized as 35 mg and above. At this dosage, users should be prepared for an intense and potentially overwhelming psychedelic experience. Effects may include extreme alterations in perception, vivid hallucinations, and a profound impact on the user's mental and emotional state.

It is crucial for individuals experimenting with 4-AcO-MiPT to approach dosage with caution, considering their experience level, set, and setting. The effects of the substance can vary widely based on individual sensitivity and other factors. Always start with a lower dosage and gradually increase if needed, keeping in mind the potential for increased intensity and duration with higher doses.

Toxicity and Harm Potential of 4-Acetoxy-N-methyl-N-isopropyltryptamine (4-AcO-MiPT)

Overview

The toxicity and long-term health effects of recreational 4-AcO-MiPT use have not been extensively studied in scientific contexts due to its status as a research chemical with limited human usage history. It is essential to note that the exact toxic dose remains unknown.

Lack of Scientific Study

As a research chemical, 4-AcO-MiPT lacks a comprehensive scientific examination regarding its toxicity and potential long-term health effects. The scarcity of human usage data contributes to the uncertainty surrounding the substance's safety profile.

Anecdotal Evidence

Anecdotal evidence suggests that trying 4-AcO-MiPT at low to moderate doses without combining it with other substances may not lead to negative health effects. However, it is crucial to recognize that no guarantees can be provided, and independent research should be conducted to ensure the safety of any substance combination.

Responsible Use

To minimize potential risks, users are strongly encouraged to employ harm reduction practices when engaging with 4-AcO-MiPT. Responsible use involves informed decision-making, cautious dosing, and a thorough understanding of individual tolerance and sensitivities.

Tolerance and Addiction Potential

Non-Habit Forming

4-AcO-MiPT is generally considered non-habit forming, and the desire to use it may decrease with regular consumption. Similar to most psychedelics, it is often perceived as self-regulating.

Tolerance Development

Tolerance to the effects of 4-AcO-MiPT builds almost immediately after ingestion. It takes approximately 3 days for tolerance to be halved and 7 days to return to baseline in the absence of further consumption. Importantly, 4-AcO-MiPT presents cross-tolerance with other psychedelics, meaning that the effects of all psychedelics are reduced after the consumption of 4-AcO-MiPT.

Dangerous Interactions

Warning on Interactions

Combining 4-AcO-MiPT with certain substances can lead to dangerous and even life-threatening interactions. Users are urged to conduct independent research to ensure the safety of any substance combination.

Known Interactions

  • Lithium: Combining with lithium, commonly prescribed for bipolar disorder, significantly increases the risk of psychosis and seizures.

  • Cannabis: There is a potential for unexpectedly strong and unpredictable synergy, increasing the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis.

  • Stimulants: Mixing with stimulants such as amphetamine, cocaine, or methylphenidate can elevate the risk of anxiety, paranoia, panic attacks, and thought loops, with an increased potential for mania and psychosis.

  • Tramadol: Known to lower the seizure threshold, tramadol combined with psychedelics may trigger seizures in susceptible individuals.

Legal Status

International Legal Status

Due to its relative obscurity, the possession and sale of 4-AcO-MiPT remain unscheduled in most countries. However, specific countries have implemented regulations:

  • Germany: Controlled under the NpSG (New Psychoactive Substances Act) since July 18, 2019, with strict penalties for production, import, administration, placement on the market, and trading. Possession is illegal but not punishable.

  • Japan: Classified as a controlled substance since March 25th, 2015.

  • Sweden: Classified as a "health hazard," making it illegal to sell or possess.

  • Switzerland: Considered an ester analog of 4-HO-MiPT, potentially making it illegal.

  • United Kingdom: Class A drug due to its ester status of 4-HO-MiPT.

  • United States: Unscheduled, but its status as an analog of psilocin (4-HO-DMT) could lead to legal consequences under the Federal Analogue Act.

FAQ (Frequently Asked Questions)

Q: What is 4-Acetoxy-N-methyl-N-isopropyltryptamine (4-AcO-MiPT)?

A: 4-AcO-MiPT is a synthetic psychedelic tryptamine, often considered the acetylated form of 4-HO-MiPT.

Q: Are there known physical effects of 4-AcO-MiPT?

A: Yes, physical effects include excessive yawning, sedation, spontaneous tactile sensations, pupil dilation, runny nose, and watery eyes.

Q: What are the cognitive effects of 4-AcO-MiPT?

A: Cognitive effects encompass analysis enhancement, conceptual thinking, delusion, autonomous voice communication, déjà vu, emotion enhancement, and more.

Q: What are the recommended dosages for 4-AcO-MiPT?

A: Dosages vary from threshold (5 mg) to heavy (35 mg+), with light (10 - 15 mg) and common (15 - 20 mg) doses in between.

Q: Is 4-AcO-MiPT habit-forming?

A: No, it is not habit-forming, and the desire to use it may decrease with regular consumption.

Q: How quickly does tolerance develop with 4-AcO-MiPT?

A: Tolerance builds almost immediately after ingestion, taking about 3 days to be reduced to half and 7 days to return to baseline.

Q: Are there dangerous interactions with 4-AcO-MiPT?

A: Yes, combining it with substances like lithium, cannabis, stimulants, and tramadol can lead to severe consequences.

Q: What is the legal status of 4-AcO-MiPT in different countries?

A: Its legal status varies globally; for instance, it is unscheduled in the United States but controlled in Germany and Japan.

Q: How should users practice harm reduction with 4-AcO-MiPT?

A: Users are strongly encouraged to conduct independent research, practice cautious dosing, and employ harm reduction practices to minimize potential risks.

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