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Table of Contents

1. Introduction
2. Chemistry
3. Pharmacology
4. Reported Effects
   • Physical Effects
   • Visual Effects
   • Cognitive Effects
   • Auditory Effects
5. Dosage
6. Reagent Results
7. Toxicity and Harm Potential
8. Tolerance and Addiction Potential
9. Dangerous Interactions
10. Legal Status

Exploring 5-MeO-MiPT: A Lesser-Known Psychedelic Tryptamine

Origins and Chemical Background

5-Methoxy-N-methyl-N-isopropyltryptamine, commonly referred to as 5-MeO-MiPT or simply moxy, belongs to the tryptamine class of psychedelic substances. This compound shares chemical similarities with other tryptamines such as 5-MeO-DMT and 5-MeO-DiPT. Its psychoactive effects primarily stem from its interaction with serotonin receptors in the brain.

Synthesis and Early Documentation

The synthesis and initial pharmacological exploration of 5-MeO-MiPT were first elucidated in 1985 by David Repke and Alexander Shulgin. Shulgin extensively documented its effects on humans in his seminal work, TiHKAL ("Tryptamines I Have Known and Loved").

Reported Effects and Experiences

Anecdotal reports from users often characterize the effects of 5-MeO-MiPT as highly stimulating and mildly entactogenic, distinct from the typical psychedelic visual distortions associated with other compounds. Users commonly note pronounced physical and tactile sensations, which may heighten libido and enhance sexual pleasure. However, a notable downside reported by many is the presence of an unpleasant "body load" experienced particularly at common to high doses, manifesting as muscle tension and nausea.

Pharmacological Understanding and Safety Concerns

Despite its intriguing effects, there remains a dearth of knowledge concerning the pharmacological properties, metabolism, and toxicity profile of 5-MeO-MiPT. Moreover, its history of human usage is relatively limited. Often marketed and sold online as a research chemical, its consumption demands a cautious approach, emphasizing the importance of harm reduction practices.

In conclusion, while 5-MeO-MiPT offers a unique pharmacological profile within the realm of psychedelics, its use warrants careful consideration and adherence to harm reduction principles due to the paucity of comprehensive understanding regarding its effects and safety profile.

Chemistry

Molecular Structure and Composition

5-MeO-MiPT, also known as 5-methoxy-N-methyl-N-isopropyltryptamine, belongs to the synthetic indole alkaloid family within the tryptamine class of molecules. Tryptamines share a fundamental structure comprising a bicyclic indole heterocycle linked at R3 to an amino group via an ethyl side chain. In the case of 5-MeO-MiPT, it is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group (CH3O−). Additionally, it contains a methyl group and an isopropyl chain bound to the terminal amine RN of its tryptamine backbone (MiPT).

5-MeO-MiPT is regarded as the N-substituted isopropyl homologue of 5-MeO-DMT.

Pharmacology

Mechanisms of Action

The psychedelic effects of 5-MeO-MiPT are primarily attributed to its efficacy at the 5-HT2A receptor, where it acts as a partial agonist. Speculation also surrounds additional mechanisms of action, such as the inhibition of monoamine oxidase (MAO) enzymes, although this remains scientifically unproven. Although 5-MeO-MiPT exhibits strong binding affinity to 5-HT1A receptors, it also demonstrates considerable affinity to the serotonin transporter (SERT) and norepinephrine transporter (NET), thereby functioning as a moderately potent serotonin-norepinephrine reuptake inhibitor (SNRI). These pharmacological actions may elucidate reports of antidepressant and anxiolytic effects following moderate doses of the compound, akin to clinically prescribed medications such as venlafaxine and buspirone.

Subjective Effects

5-MeO-MiPT can be administered orally or via smoking, each route altering the character of its effects. Orally ingested doses reportedly accentuate visual and sensory experiences, characterized by a biphasic progression. The initial phase is described as stimulating and entactogenic, transitioning into a second phase reminiscent of traditional tryptamine psychedelics like psilocybin mushrooms or LSD. Smoking the compound amplifies its physically and cognitively stimulating effects.

Disclaimer: The subjective effects outlined below are derived from the Subjective Effect Index (SEI), based on anecdotal user accounts and personal analyses from contributors to PsychonautWiki. These effects should be approached with skepticism, as they may not manifest predictably or reliably. Moreover, higher doses are associated with increased likelihood of experiencing the full spectrum of effects, including adverse outcomes such as addiction, severe injury, or fatality.

Dosage

Threshold

The threshold dose for 5-MeO-MiPT is approximately 3 milligrams (mg).

Light

A light dose of 5-MeO-MiPT typically ranges from 3 to 7 milligrams (mg).

Common

Common doses of 5-MeO-MiPT fall within the range of 7 to 15 milligrams (mg).

Strong

Strong doses of 5-MeO-MiPT are typically between 15 and 20 milligrams (mg).

Heavy

A heavy dose of 5-MeO-MiPT is considered to be 20 milligrams (mg) or higher.

Physical Effects

Stimulation

At doses below 10 to 15 milligrams (mg), 5-MeO-MiPT induces a level of stimulation akin to that experienced with LSD.

Spontaneous Bodily Sensations

The "body high" associated with 5-MeO-MiPT is often described as a pleasurable, warm, and encompassing glow. Users may also experience a cold, sharp tingling sensation that arises unpredictably throughout the experience, intensifying as the peak is reached.

Nausea

Nausea is a commonly reported side effect of 5-MeO-MiPT, occasionally leading to vomiting. However, this discomfort typically diminishes after the initial come-up phase. Notably, 5-MeO-MiPT exhibits a lower tendency to provoke unpleasant physical reactions compared to 5-MeO-DiPT.

Bodily Pressures

Other physical effects may include abnormal heartbeat, increased heart rate, increased blood pressure, headaches (though citations are needed for these effects), dehydration, stomach bloating (particularly at higher doses), pupil dilation, vasoconstriction, and diarrhea.

Visual Effects

Enhancements

• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement

Distortions

• Drifting (Melting, Breathing, Warping, and Flowing): This effect is characterized by highly detailed, slow, and smooth motion.
• Tracers
• Afterimages
• Symmetrical texture repetition
• Colour shifting
• Scenery slicing

Geometry

The visual geometry induced by 5-MeO-MiPT resembles that of Psilocin, 4-AcO-DMT, or ayahuasca more than LSD or 2C-B. It is intricate, abstract, brightly lit, multicoloured, glossy, and exhibits both blurred and sharp edges. The geometry is large in size, fast in speed, smooth in motion, and varies in rounded and angular corners. At higher doses, it is more likely to result in level 8B visual geometry.

Hallucinatory States

5-MeO-MiPT can induce a full spectrum of high-level hallucinatory states more consistently than many other psychedelics.

Transformations

Internal hallucination: Users may experience autonomous entities, settings, sceneries, landscapes, perspective hallucinations, scenarios, and plots. These hallucinations are more prevalent in darkness and vary in believability, interactivity, content, controllability, and theme, often aligning with personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical, or transcendental motifs.

Cognitive Effects

Insight and Relaxation

At low to moderate doses, users often describe the cognitive effects of 5-MeO-MiPT as insightful and moderately relaxing, with occasional stimulating aspects. These effects are typical of many psychedelics and become more pronounced with increasing dosage. However, at higher doses, the compound tends to induce primarily sedating and impairing effects, accompanied by depersonalization and a lack of insight.

Analysis Enhancement

5-MeO-MiPT may enhance analytical thinking processes, allowing users to delve deeper into thoughts and concepts.

Empathy, Affection, and Sociability Enhancement

In social settings, 5-MeO-MiPT can enhance feelings of empathy, love, and sociability, though to a lesser degree compared to substances like MDMA and 2C-B. Nevertheless, these effects can still provide therapeutic benefits.

Depersonalization

Unlike most traditional psychedelics, 5-MeO-MiPT has the potential to induce extreme depersonalization and dissociation in some users throughout the experience.

Conceptual Thinking

Users may experience heightened conceptual thinking, leading to profound insights and perspectives.

Increased Music Appreciation

Music appreciation is often intensified under the influence of 5-MeO-MiPT, with sounds perceived as richer and more profound.

Emotion Enhancement

Emotional experiences may be intensified, leading to deeper emotional connections and understanding.

Increased Libido

Many users report an increase in libido while under the effects of 5-MeO-MiPT.

Memory Suppression

The compound may suppress short-term memory, leading to difficulty recalling recent events or information.

Novelty Enhancement

Perception of novelty and interest in mundane experiences may be heightened.

Personal Bias Suppression

Users may experience a reduction in personal biases and preconceptions, leading to a more open-minded perspective.

Thought Acceleration

Thought processes may speed up, leading to rapid ideation and cognitive processing.

Thought Connectivity

Users may perceive enhanced connectivity between thoughts and ideas, leading to a more cohesive understanding of concepts.

Time Distortion

Perception of time may become distorted, with minutes feeling like hours or vice versa.

Wakefulness

5-MeO-MiPT may promote wakefulness, keeping users alert and engaged with their surroundings.

Auditory Effects

Enhancements

The perception of auditory stimuli may be enhanced, making sounds more vibrant and immersive.

Distortions

Auditory distortions, such as changes in pitch or tone, may occur.

Hallucinations

Users may experience auditory hallucinations, perceiving sounds that are not present in reality.

Toxicity and Harm Potential

Almost nothing is known about the long-term effects of 5-MeO-MiPT, and the exact toxic dosage remains unknown due to its status as a research chemical with limited human usage history.

A preliminary study on mice showed that a normal dose of 5-MeO-MiPT (0.27 mg/kg) didn't produce measurable toxic effects. However, doses significantly higher than the normal range (2.7 mg/kg) caused cell toxicity by triggering programmed cell death in the brain, liver, and kidneys. The extent and nature of this damage in other bodily tissues are yet to be fully understood.

Anecdotal evidence suggests that low to moderate doses of 5-MeO-MiPT used sparingly do not result in negative health effects. However, caution is advised, and independent research should be conducted to ensure safety, especially when combining with other substances.

Tolerance and Addiction Potential

5-MeO-MiPT is not considered habit-forming, and the desire to use it may decrease with use. Tolerance to its effects develops rapidly after ingestion, taking approximately 3 days to reduce to half and about 7 days to return to baseline in the absence of further consumption. Cross-tolerance with other psychedelics is observed, leading to reduced effects after consumption.

Dangerous Interactions

Combining 5-MeO-MiPT with certain substances can pose serious risks, including serotonin syndrome, psychosis, and excessive stimulation. Users should conduct thorough research to ensure the safety of combinations before consumption.

Legal Status

The legal status of 5-MeO-MiPT varies globally:

• Austria, Brazil, China, Finland, Germany, Japan, Latvia, New Zealand, Romania, Switzerland, and the United Kingdom have various degrees of prohibition.
• The United States lists it as unscheduled but prosecutable under the Federal Analogue Act.
• Some states within the United States, such as Florida, Louisiana, and Minnesota, have categorized it as a Schedule I drug.

Frequently Asked Questions (FAQ)

1. What is 5-MeO-MiPT?

5-MeO-MiPT, also known as moxy, is a lesser-known psychedelic substance belonging to the tryptamine class.

2. What are the main effects of 5-MeO-MiPT?

The effects of 5-MeO-MiPT include physical sensations, visual distortions, altered cognition, and auditory enhancements.

3. How is 5-MeO-MiPT dosed?

Dosages of 5-MeO-MiPT range from threshold levels of 3 mg to heavy doses of 20 mg or more.

4. Are there any reagent tests available for 5-MeO-MiPT?

Yes, reagent tests such as Marquis, Mecke, Mandelin, Liebermann, Ehrlich, Hofmann, and Simon's can be used to identify 5-MeO-MiPT.

5. Is 5-MeO-MiPT safe to use?

The long-term effects and exact toxic dosage of 5-MeO-MiPT are unknown due to limited research. Caution should be exercised, especially when combining with other substances.

6. Can one develop tolerance or addiction to 5-MeO-MiPT?

5-MeO-MiPT is not considered habit-forming, and tolerance to its effects develops rapidly. However, cross-tolerance with other psychedelics is observed.

7. Are there any dangerous interactions with 5-MeO-MiPT?

Combining 5-MeO-MiPT with certain substances can pose serious risks, including serotonin syndrome, psychosis, and excessive stimulation. Thorough research should be conducted before consumption.

8. What is the legal status of 5-MeO-MiPT?

The legal status of 5-MeO-MiPT varies globally, with some countries prohibiting its production, sale, and possession, while others have not yet regulated it. Users should be aware of local laws before acquiring or using the substance.