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Table of Contents:

1. Introduction

   • Definition and Overview
   • Chemical Structure and Classification

2. Chemistry

   • Molecular Composition and Structure
   • Pharmacology
     • Hydrolysis and Metabolic Fate

3. Dosage

   • Threshold
   • Light
   • Common
   • Strong
   • Heavy

4. Subjective Effects

   • Disclaimer
   • Unpredictability and Dose-Dependency
   • Subjective Effect Categories
     • Visual Effects
     • Cognitive Effects
     • Somatic Effects
     • Auditory Effects
   • Conclusion

5. Physical Effects

   • Sedation
   • Spontaneous Physical Sensations
   • Changes in Felt Bodily Form
   • Muscle Contractions and Relaxation
   • Excessive Yawning and Other Effects

6. Visual Effects

   • Enhancements and Distortions
   • Drifting and Other Distortions
   • Visual Geometry
   • Hallucinatory States

7. Cognitive Effects

   • Relaxing Yet Fast-Paced Cognitive Style
   • Immersive and Thought-Provoking

8. Toxicity, Tolerance, and Addiction Potential

   • Limited Scientific Study
   • Harm Reduction
   • Tolerance and Addiction
   • Dangerous Interactions

9. Legal Status

   • Overview and Disclaimer
   • Country-Specific Regulations
     • Germany
     • Switzerland
     • United Kingdom
     • United States

Introduction to 4-AcO-MET

4-Acetoxy-N-methyl-N-ethyltryptamine, commonly known as 4-AcO-MET, Metacetin, or Azomet, belongs to the tryptamine class of novel psychedelic substances. Within this group, substances induce psychedelic effects reminiscent of psilocybin when ingested. Structurally, 4-AcO-MET bears resemblance to other psychedelic tryptamines such as 4-AcO-DMT, 4-AcO-DET, and 4-AcO-MiPT.

Structural Relationship with 4-HO-MET

A noteworthy feature of 4-AcO-MET is its structural similarity to 4-HO-MET, leading to the hypothesis that it may function as a prodrug for the latter. The substance has been identified sporadically in pressed pills circulating in northern Switzerland, often being sold under the street names "Acomet" or "Azomet."

Limited Data and Research

Despite its intriguing properties, there is a scarcity of information regarding the pharmacological attributes, metabolism, and toxicity of 4-AcO-MET. Its historical usage among humans is minimal, and it is primarily marketed as a research chemical available for purchase online.

Harm Reduction Practices

Due to the lack of comprehensive data, caution is strongly recommended for those considering the use of 4-AcO-MET. As a substance sold online for research purposes, it falls within the realm of research chemicals. Users are advised to adopt rigorous harm reduction practices to mitigate potential risks associated with its consumption.

Chemistry of 4-AcO-MET

Molecular Composition and Structure

4-AcO-MET, scientifically termed 4-Acetoxy-N-methyl-N-ethyltryptamine, stands as a synthetic indole alkaloid within the tryptamine class. The tryptamine molecules share a foundational structure, featuring a bicyclic indole heterocycle connected at R3 to an amino group through an ethyl side chain. Specifically, 4-AcO-MET presents an acetoxy (AcO) functional group CH3COO− at the R4 position of its indole heterocycle. Additionally, it incorporates a methyl group and an ethyl chain bound to the terminal amine RN, defining its tryptamine backbone. Notably, 4-AcO-MET serves as the acetate ester analog of 4-HO-MET and the N-substituted ethyl homolog of 4-AcO-DMT.

Pharmacological Insights

Rapid Hydrolysis and Metabolism

A prevailing hypothesis suggests that 4-AcO-MET undergoes rapid hydrolysis into the free phenolic 4-HO-MET, catalyzed by serum esterases. Unfortunately, the dearth of human studies on the metabolic fate of this substance leaves a critical gap in understanding its physiological journey.

5-HT2A Receptor Interaction

The psychedelic effects attributed to 4-AcO-MET are thought to arise from its activity at the 5-HT2A receptor, functioning as a partial agonist. However, the intricate nature of these receptor interactions and their manifestation in the psychedelic experience remains a topic of ongoing exploration.

Parallel with 4-HO-MET

A parallel can be drawn with the hypothesis that 4-AcO-MET, akin to 4-AcO-DMT, may be swiftly hydrolyzed into 4-HO-MET. This proposed metabolic transformation could elucidate the observed similarities in subjective effects between the two compounds. The analogy extends to the conversion of 4-AcO-DMT to 4-HO-DMT during first-pass metabolism and subsequent liver passes.

In conclusion, the chemistry of 4-AcO-MET unveils a complex interplay of molecular structures and potential metabolic pathways. The conjecture surrounding its conversion to 4-HO-MET and the involvement of 5-HT2A receptors paves the way for future research endeavors to unravel the intricacies of this intriguing psychedelic tryptamine.

Navigating 4-AcO-MET Dosages

Understanding Threshold Effects

The dosage spectrum of 4-AcO-MET, a synthetic indole alkaloid within the tryptamine class, delineates distinct thresholds for various experiential intensities.

Dosage Guidelines

Light Experience (10 - 20 mg)

At this dosage range, users can anticipate a light psychedelic encounter with the effects of 4-AcO-MET manifesting subtly. This range is ideal for those seeking a gentle introduction to its psychoactive properties.

Common Territory (20 - 30 mg)

Stepping into the common dosage zone, users may experience more pronounced psychedelic effects. This range is often chosen by individuals seeking a moderate yet well-defined psychedelic experience, striking a balance between intensity and manageability.

Strong Effects (30 - 50 mg)

The strong dosage range of 30 to 50 mg ushers in a more robust and immersive psychedelic encounter. Users in this territory should be prepared for intensified effects, potentially delving deeper into the realms of altered perception and profound introspection.

Heavy Exploration (50 mg +)

Venturing into the heavy dosage category, users surpass the 50 mg threshold, signaling a potent and potentially overwhelming psychedelic experience. Extreme caution is advised at this level, as the effects can be intense and challenging, requiring a seasoned and prepared mindset.

In summary, the dosages of 4-AcO-MET span a spectrum from threshold to heavy, offering users the flexibility to tailor their experiences based on their desired intensity. However, adherence to these dosage guidelines is crucial for ensuring a safe and enjoyable exploration of the psychedelic effects associated with 4-AcO-MET.

Subjective Effects of 4-AcO-MET

Introduction and Disclaimers

Before delving into the subjective effects of 4-AcO-MET, it's essential to acknowledge the source of information – the Subjective Effect Index (SEI). The SEI is derived from anecdotal user reports and personal analyses contributed by PsychonautWiki contributors. However, users should approach these findings with a healthy dose of skepticism.

Unpredictability and Dose-Dependency

The effects listed below are not guaranteed to occur predictably or reliably, as individual responses can vary. Higher doses, though, are more likely to induce the full spectrum of effects associated with 4-AcO-MET. It's crucial to recognize that, as doses increase, the likelihood of adverse effects also rises. These adverse effects can range from addiction to severe injury or, in extreme cases, death.

Subjective Effect Categories

Visual Effects

Enhancements

• Vibrant colors
• Visual distortions

Distortions

• Tracers
• Afterimages

Cognitive Effects

Introspection

• Deep self-reflection
• Enhanced introspective thoughts

Conceptual Thinking

• Altered perspectives
• Novel ideas

Somatic Effects

Physical Discomfort

• Nausea
• Body tension

Sedation

• Calmness
• Relaxation

Auditory Effects

Distortions

• Altered perception of sound
• Auditory hallucinations

Emotional Effects

Euphoria

• Heightened sense of happiness
• Emotional warmth

Anxiety

• Nervousness
• Restlessness

Conclusion

In conclusion, the subjective effects of 4-AcO-MET encompass a diverse array of experiences, spanning visual, cognitive, somatic, auditory, and emotional realms. However, users should approach these effects with caution, considering the inherent unpredictability and dose-dependent nature of 4-AcO-MET. The disclaimer serves as a reminder of the potential risks associated with higher doses, emphasizing the importance of responsible usage and informed decision-making.