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Product Name: 4-AcO-MET
IUPAC Name: 3-(2-Ethyl(methyl)aminoethyl)-1H-indol-4-yl acetate
Other Names: 4-AcO-MET, 4-Acetoxy-MET, Metacetin, O-Acetylmetocin
Molecular Formula: None
Molar Mass: 237.26 g·mol−1
Effect: stimulant, psychedelic
Purity of the substance: 99.9%
Physical properties: Crystals, Powder
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Table of Contents:

  1. Introduction

    • Definition and Overview
    • Chemical Structure and Classification
  2. Chemistry

    • Molecular Composition and Structure
    • Pharmacology
      • Hydrolysis and Metabolic Fate
  3. Dosage

    • Threshold
    • Light
    • Common
    • Strong
    • Heavy
  4. Subjective Effects

    • Disclaimer
    • Unpredictability and Dose-Dependency
    • Subjective Effect Categories
      • Visual Effects
      • Cognitive Effects
      • Somatic Effects
      • Auditory Effects
    • Conclusion
  5. Physical Effects

    • Sedation
    • Spontaneous Physical Sensations
    • Changes in Felt Bodily Form
    • Muscle Contractions and Relaxation
    • Excessive Yawning and Other Effects
  6. Visual Effects

    • Enhancements and Distortions
    • Drifting and Other Distortions
    • Visual Geometry
    • Hallucinatory States
  7. Cognitive Effects

    • Relaxing Yet Fast-Paced Cognitive Style
    • Immersive and Thought-Provoking
  8. Toxicity, Tolerance, and Addiction Potential

    • Limited Scientific Study
    • Harm Reduction
    • Tolerance and Addiction
    • Dangerous Interactions
  9. Legal Status

    • Overview and Disclaimer
    • Country-Specific Regulations
      • Germany
      • Switzerland
      • United Kingdom
      • United States

Introduction to 4-AcO-MET

4-Acetoxy-N-methyl-N-ethyltryptamine, commonly known as 4-AcO-MET, Metacetin, or Azomet, belongs to the tryptamine class of novel psychedelic substances. Within this group, substances induce psychedelic effects reminiscent of psilocybin when ingested. Structurally, 4-AcO-MET bears resemblance to other psychedelic tryptamines such as 4-AcO-DMT, 4-AcO-DET, and 4-AcO-MiPT.

Structural Relationship with 4-HO-MET

A noteworthy feature of 4-AcO-MET is its structural similarity to 4-HO-MET, leading to the hypothesis that it may function as a prodrug for the latter. The substance has been identified sporadically in pressed pills circulating in northern Switzerland, often being sold under the street names "Acomet" or "Azomet."

Limited Data and Research

Despite its intriguing properties, there is a scarcity of information regarding the pharmacological attributes, metabolism, and toxicity of 4-AcO-MET. Its historical usage among humans is minimal, and it is primarily marketed as a research chemical available for purchase online.

Harm Reduction Practices

Due to the lack of comprehensive data, caution is strongly recommended for those considering the use of 4-AcO-MET. As a substance sold online for research purposes, it falls within the realm of research chemicals. Users are advised to adopt rigorous harm reduction practices to mitigate potential risks associated with its consumption.

Chemistry of 4-AcO-MET

Molecular Composition and Structure

4-AcO-MET, scientifically termed 4-Acetoxy-N-methyl-N-ethyltryptamine, stands as a synthetic indole alkaloid within the tryptamine class. The tryptamine molecules share a foundational structure, featuring a bicyclic indole heterocycle connected at R3 to an amino group through an ethyl side chain. Specifically, 4-AcO-MET presents an acetoxy (AcO) functional group CH3COO− at the R4 position of its indole heterocycle. Additionally, it incorporates a methyl group and an ethyl chain bound to the terminal amine RN, defining its tryptamine backbone. Notably, 4-AcO-MET serves as the acetate ester analog of 4-HO-MET and the N-substituted ethyl homolog of 4-AcO-DMT.

Pharmacological Insights

Rapid Hydrolysis and Metabolism

A prevailing hypothesis suggests that 4-AcO-MET undergoes rapid hydrolysis into the free phenolic 4-HO-MET, catalyzed by serum esterases. Unfortunately, the dearth of human studies on the metabolic fate of this substance leaves a critical gap in understanding its physiological journey.

5-HT2A Receptor Interaction

The psychedelic effects attributed to 4-AcO-MET are thought to arise from its activity at the 5-HT2A receptor, functioning as a partial agonist. However, the intricate nature of these receptor interactions and their manifestation in the psychedelic experience remains a topic of ongoing exploration.

Parallel with 4-HO-MET

A parallel can be drawn with the hypothesis that 4-AcO-MET, akin to 4-AcO-DMT, may be swiftly hydrolyzed into 4-HO-MET. This proposed metabolic transformation could elucidate the observed similarities in subjective effects between the two compounds. The analogy extends to the conversion of 4-AcO-DMT to 4-HO-DMT during first-pass metabolism and subsequent liver passes.

In conclusion, the chemistry of 4-AcO-MET unveils a complex interplay of molecular structures and potential metabolic pathways. The conjecture surrounding its conversion to 4-HO-MET and the involvement of 5-HT2A receptors paves the way for future research endeavors to unravel the intricacies of this intriguing psychedelic tryptamine.

Navigating 4-AcO-MET Dosages

Understanding Threshold Effects

The dosage spectrum of 4-AcO-MET, a synthetic indole alkaloid within the tryptamine class, delineates distinct thresholds for various experiential intensities.

Dosage Guidelines

Light Experience (10 - 20 mg)

At this dosage range, users can anticipate a light psychedelic encounter with the effects of 4-AcO-MET manifesting subtly. This range is ideal for those seeking a gentle introduction to its psychoactive properties.

Common Territory (20 - 30 mg)

Stepping into the common dosage zone, users may experience more pronounced psychedelic effects. This range is often chosen by individuals seeking a moderate yet well-defined psychedelic experience, striking a balance between intensity and manageability.

Strong Effects (30 - 50 mg)

The strong dosage range of 30 to 50 mg ushers in a more robust and immersive psychedelic encounter. Users in this territory should be prepared for intensified effects, potentially delving deeper into the realms of altered perception and profound introspection.

Heavy Exploration (50 mg +)

Venturing into the heavy dosage category, users surpass the 50 mg threshold, signaling a potent and potentially overwhelming psychedelic experience. Extreme caution is advised at this level, as the effects can be intense and challenging, requiring a seasoned and prepared mindset.

In summary, the dosages of 4-AcO-MET span a spectrum from threshold to heavy, offering users the flexibility to tailor their experiences based on their desired intensity. However, adherence to these dosage guidelines is crucial for ensuring a safe and enjoyable exploration of the psychedelic effects associated with 4-AcO-MET.

Subjective Effects of 4-AcO-MET

Introduction and Disclaimers

Before delving into the subjective effects of 4-AcO-MET, it's essential to acknowledge the source of information – the Subjective Effect Index (SEI). The SEI is derived from anecdotal user reports and personal analyses contributed by PsychonautWiki contributors. However, users should approach these findings with a healthy dose of skepticism.

Unpredictability and Dose-Dependency

The effects listed below are not guaranteed to occur predictably or reliably, as individual responses can vary. Higher doses, though, are more likely to induce the full spectrum of effects associated with 4-AcO-MET. It's crucial to recognize that, as doses increase, the likelihood of adverse effects also rises. These adverse effects can range from addiction to severe injury or, in extreme cases, death.

Subjective Effect Categories

Visual Effects


  • Vibrant colors
  • Visual distortions


  • Tracers
  • Afterimages

Cognitive Effects


  • Deep self-reflection
  • Enhanced introspective thoughts

Conceptual Thinking

  • Altered perspectives
  • Novel ideas

Somatic Effects

Physical Discomfort

  • Nausea
  • Body tension


  • Calmness
  • Relaxation

Auditory Effects


  • Altered perception of sound
  • Auditory hallucinations

Emotional Effects


  • Heightened sense of happiness
  • Emotional warmth


  • Nervousness
  • Restlessness


In conclusion, the subjective effects of 4-AcO-MET encompass a diverse array of experiences, spanning visual, cognitive, somatic, auditory, and emotional realms. However, users should approach these effects with caution, considering the inherent unpredictability and dose-dependent nature of 4-AcO-MET. The disclaimer serves as a reminder of the potential risks associated with higher doses, emphasizing the importance of responsible usage and informed decision-making.

Physical Effects


Considered relaxing and mildly sedating, 4-AcO-MET induces a sense of tranquility often accompanied by compulsive yawning. Notably, its sedative properties are deemed less potent than those of related compounds like psilocin and 4-AcO-DMT.

Spontaneous Physical Sensations

The "body high" associated with 4-AcO-MET is characterized by a pleasurable, warm, and all-encompassing tingling sensation. This sensation steadily rises with onset, reaching its peak during the experience.

Changes in Felt Bodily Form

Users may experience alterations in bodily form, accompanied by a sense of warmth. This phenomenon occurs typically around or after the peak, with users reporting a feeling of being physically connected or conjoined with other objects, evoking comfort or, in some cases, bodily tension.

Muscle Contractions and Relaxation

Transient and benign muscle contractions are noted, distinguishing 4-AcO-MET from other tryptamines, phenethylamines, and lysergamides. Muscle relaxation is also observed.

Excessive Yawning and Other Effects

Unique to substances like psilocin and related tryptamines, excessive yawning is pronounced. Additional effects include watery eyes, olfactory hallucinations, pupil dilation, runny nose, increased salivation, teeth grinding (of lesser intensity compared to substances like MDMA), and nausea.

Visual Effects

Enhancements and Distortions

  • Enhancements: Vibrant colors, visual distortions.
  • Distortions: Tracers, afterimages.

Drifting and Other Distortions

  • Drifting: Highly detailed, cartoon-like, slow and smooth motion.
  • After Images, Colour Shifting, Environmental Patterning, Scenery Slicing, Symmetrical Texture Repetition, Tracers.

Visual Geometry

The visual geometry of 4-AcO-MET shares similarities with psilocin, 4-AcO-DMT, and 4-HO-MiPT. It features intricate, abstract, synthetic, and organic elements, with strong "synthetic" digital undertones comparable to 2C-B. Higher dosages may lead to level 8A visual geometry.

Hallucinatory States

4-AcO-MET induces a range of high-level hallucinatory states, including transformations and internal hallucinations. These experiences often occur in dark environments at appropriate dosages.

Cognitive Effects

Relaxing Yet Fast-Paced Cognitive Style

The cognitive effects of 4-AcO-MET are often described as somewhat relaxing but fast-paced, akin to psychedelics like LSD or 2C-B. Notable cognitive effects include analysis enhancement, conceptual thinking, delusion, ego death, emotion enhancement, and perception of interdependent opposites.

Immersive and Thought-Provoking

Other cognitive effects include increased music appreciation, memory suppression, novelty enhancement, thought acceleration, thought connectivity, thought loops, time distortion, unity, interconnectedness, wakefulness, brain zaps, and auditory effects.

Toxicity, Tolerance, and Addiction Potential

Limited Scientific Study

The toxicity and long-term health effects of recreational 4-AcO-MET use lack comprehensive scientific study, given its status as a research chemical with minimal human usage history.

Harm Reduction

Anecdotal evidence suggests no negative health effects at low to moderate doses. However, harm reduction practices are strongly recommended, and independent research should precede any substance combination.

Tolerance and Addiction

4-AcO-MET is not habit-forming and may lead to decreased desire with use. Immediate tolerance builds after ingestion, taking about 3 days to reduce by half and 7 days to return to baseline. Cross-tolerance with other psychedelics is noted.

Dangerous Interactions

Cautionary Notes

Several potential dangerous interactions are highlighted, including combining 4-AcO-MET with lithium, cannabis, stimulants, and tramadol. Independent research is essential to ensure the safety of substance combinations.

In conclusion, the comprehensive overview sheds light on the multifaceted effects of 4-AcO-MET, emphasizing the importance of responsible usage, harm reduction, and informed decision-making.

Legal Status of 4-AcO-MET

Overview and Disclaimer

This legal status section provides a snapshot of the regulatory framework surrounding 4-AcO-MET, acknowledging that the information presented may be incomplete or subject to change. Readers are encouraged to contribute to its expansion for accuracy.

Country-Specific Regulations


As of July 18, 2019, 4-AcO-MET is regulated under the NpSG (New Psychoactive Substances Act) in Germany. The act prohibits production and import with the intent to place it on the market, administration to others, placing it on the market, and trading. While possession is illegal, it is not punishable. The legislative perspective considers the possibility of ordering 4-AcO-MET as potentially punishable, akin to an incitement to place it on the market.


In Switzerland, 4-AcO-MET falls under controlled substances, specifically listed under Verzeichnis E.

United Kingdom

The United Kingdom classifies 4-AcO-MET as a Class A drug. This designation stems from its status as an ester of 4-HO-MET, itself a Class A drug due to the tryptamine catch-all clause.

United States

In the United States, 4-AcO-MET is currently unscheduled. However, it may be considered an analogue of psilocin (4-HO-DMT), which is a Schedule I drug under the Controlled Substances Act. Consequently, selling it for human consumption or using it for illicit non-medical or industrial purposes could lead to prosecution under the Federal Analogue Act.

In conclusion, the legal status of 4-AcO-MET varies across countries, with Germany and the United Kingdom imposing stricter regulations compared to the United States, where it remains unscheduled but subject to potential prosecution under specific circumstances. Users and researchers should stay informed about legal developments to ensure compliance with relevant regulations.


Q1: What is 4-AcO-MET?

A1: 4-AcO-MET is a synthetic indole alkaloid classified under the tryptamine class, known for its psychedelic effects similar to psilocybin.

Q2: How is 4-AcO-MET related to other substances?

A2: Structurally related to 4-HO-MET, it is theorized to act as a prodrug. It shares connections with psychedelic tryptamines like 4-AcO-DMT, 4-AcO-DET, and 4-AcO-MiPT.

Q3: What are the recommended dosages?

A3: Dosages range from 5 mg (threshold) to 50 mg and beyond (heavy), with effects intensifying at higher doses. Users are advised to adhere to harm reduction practices.

Q4: What are the subjective effects of 4-AcO-MET?

A4: Subjective effects encompass visual, cognitive, somatic, auditory, and emotional realms. However, individual responses vary, and caution is urged due to potential unpredictability.

Q5: What are the legal implications of 4-AcO-MET?

A5: Legal status varies by country. For example, it is controlled in Germany and Switzerland, classified as a Class A drug in the UK, and remains unscheduled but subject to potential prosecution in the US.

Q6: Is 4-AcO-MET habit-forming?

A6: No, 4-AcO-MET is not habit-forming, and the desire to use it can decrease with use. Tolerance builds quickly, leading to self-regulation.

Q7: Are there dangerous interactions with other substances?

A7: Yes, potential dangerous interactions exist, especially with lithium, cannabis, stimulants, and tramadol. Independent research is crucial to ensure safe substance combinations.

Q8: How is 4-AcO-MET metabolized in the body?

A8: While it is hypothesized to be hydrolyzed into the free phenolic 4-HO-MET, human studies on its metabolic fate are lacking, leaving aspects of its physiological journey unclear.

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