Diethyltryptamine (DET) research chemical

Table of Contents:

  1. Introduction

    1.1 Background

    1.2 Transmethylation Hypothesis

  2. Chemistry

    2.1 Molecular Structure of DET

    2.2 Analogues and Derivatives

    2.3 Production and Synthetic Chemicals

  3. Pharmacology

    3.1 Lack of Research and Speculations

    3.2 5-HT2A Partial Agonist

    3.3 Orally Active Characteristics

  4. Subjective Effects

    4.1 Physical Effects

    4.1.1 Stimulation

    4.1.2 Spontaneous Physical Sensations

    4.1.3 Cardiovascular Effects

    4.2 Visual Effects

    4.2.1 Enhancements

    4.2.2 Distortions

    4.2.3 Hallucinatory States

    4.3 Cognitive Effects

    4.3.1 Cognitive Euphoria

    4.3.2 Memory Suppression

    4.3.3 Thought Loops

    4.4 Auditory Effects

    4.4.1 Enhancements

    4.4.2 Distortions

    4.4.3 Hallucinations

  5. FAQ (Frequently Asked Questions)

    5.1 What is Diethyltryptamine (DET)?

    5.2 How does DET differ from DMT?

    5.3 What are the potential therapeutic applications of DET?

    5.4 Are there any known risks or side effects associated with DET use?


Introduction

1.1 Background

Diethyltryptamine (DET), also known as N,N-DET, is a synthetic psychedelic tryptamine closely related to Dimethyltryptamine (DMT). Despite its rarity, DET has been subject to limited human usage, and its origins trace back to the 1950s.

1.2 Transmethylation Hypothesis

During the 1950s, the transmethylation hypothesis emerged, suggesting that the endogenous production of psychoactive agents might explain hallucinatory symptoms in certain psychiatric diseases. This hypothesis laid the foundation for early studies on DET and other psychedelics, focusing on their psychotomimetic properties.

Chemistry

2.1 Molecular Structure of DET

DET is a synthetic indole alkaloid belonging to the tryptamine class. It shares a core structure with other tryptamines, featuring a bicyclic indole heterocycle attached to an amino group via an ethyl side chain.

2.2 Analogues and Derivatives

DET has various substituted analogues, including 4-HO-DET ("ethocin"). It is an analogue of the common tryptamine hallucinogen DMT. While DET is synthetic, it has been used in combination with Psilocybe cubensis mycelium to produce synthetic chemicals like 4-PO-DET (Ethocybin) and 4-HO-DET (Ethocin).

2.3 Production and Synthetic Chemicals

Isolation of alkaloids from DET synthesis resulted in 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET, showcasing its potential in creating other psychoactive compounds.

Pharmacology

3.1 Lack of Research and Speculations

Due to limited research, discussions on DET's pharmacology are speculative, relying on its structure and subjective effects akin to other tryptamine psychedelics like psilocin and DMT.

3.2 5-HT2A Partial Agonist

DET is theorized to act as a 5-HT2A partial agonist, differing from DMT. The ethyl groups in DET provide protection against the monoamine oxidase enzyme system, enabling oral activity.

3.3 Orally Active Characteristics

DET's oral activity distinguishes it from DMT, which requires alternative administration methods due to monoamine oxidase degradation. The ethyl groups in DET prevent such degradation, a feature shared with other tryptamines with larger nitrogen substituents.

Subjective Effects

4.1 Physical Effects

  • 4.1.1 Stimulation
  • 4.1.2 Spontaneous Physical Sensations
  • 4.1.3 Cardiovascular Effects

4.2 Visual Effects

  • 4.2.1 Enhancements
  • 4.2.2 Distortions
  • 4.2.3 Hallucinatory States

4.3 Cognitive Effects

  • 4.3.1 Cognitive Euphoria
  • 4.3.2 Memory Suppression
  • 4.3.3 Thought Loops

4.4 Auditory Effects

  • 4.4.1 Enhancements
  • 4.4.2 Distortions
  • 4.4.3 Hallucinations

FAQ 

5.1 What is Diethyltryptamine (DET)?

DET is a synthetic psychedelic tryptamine, closely related to DMT, with limited human usage and a history dating back to the 1950s.

5.2 How does DET differ from DMT?

DET is an analogue of DMT, distinguished by its synthetic nature and the ability to be taken orally due to ethyl group protection against monoamine oxidase.

5.3 What are the potential therapeutic applications of DET?

The therapeutic potential of DET remains speculative due to limited research; however, its structural similarities to other psychedelics may warrant further exploration.

5.4 Are there any known risks or side effects associated with DET use?

As DET is uncommon and lacks extensive research, potential risks and side effects are not well-established. Caution and responsible use are advised.