3,5-Dimethoxy-4-propoxyamphetamine (3C-P): Unveiling a Lesser-Known Psychedelic

Summary

3,5-Dimethoxy-4-propoxyamphetamine, commonly known as 3C-P or 3C-Proscaline, belongs to the amphetamine class, distinguished by its psychedelic properties. Despite its name hinting at a connection with the 2C-x family, it is, in fact, the 3-carbon analog of proscaline. This compound has an uncertain synthesis date and is featured in Alexander Shulgin's PiHKAL with speculated psychedelic properties and a suggested dosage range of 20 to 40 milligrams. Sold primarily on the online research chemical market, 3C-P has limited data regarding its pharmacology, metabolism, and toxicity, emphasizing the importance of practicing harm reduction when using this substance.

Chemistry

3C-P, or 3,5-Dimethoxy-4-propoxyamphetamine, is a substituted amphetamine featuring a phenyl ring bound to an amino group through an ethyl chain, with a methyl group attached to the alpha carbon. Methoxy functional groups (OCH3) are connected to carbons R3 and R5, and a propoxy chain (OCH2CH2CH3) is attached to carbon R4 of the phenyl ring.

Pharmacology

Contrary to its name's suggestion of a connection to the 2C-x family, 3C-P is the 3-carbon analog of proscaline. Its pharmacology involves a robust interaction with 5-HT2A receptors, potentially offering relief from cluster headaches or alleviating psychological suffering linked to end-stage cancer.

The psychedelic effects of 3C-P are believed to stem from its efficacy at the 5-HT2A receptor as a partial agonist. However, the precise mechanisms of these interactions and their role in producing the psychedelic experience remain elusive.

In the realm of structure-activity-relationships between mescaline analogs, 3C-P stands out for its potency, surpassing mescaline and TMA-2. Animal studies suggest its similarity in potency to 3C-E, with predictions from a rat-based study indicating comparable effects and dosages to 3C-E.

Conclusion

3,5-Dimethoxy-4-propoxyamphetamine, while intriguing for its psychedelic potential, remains shrouded in limited information. Its chemistry and pharmacology hint at unique properties, but caution and harm reduction practices are essential for anyone considering its usage due to the scarce data on its metabolism and toxicity. The psychedelic community and researchers alike await further exploration into the mysteries surrounding 3C-P.

Frequently Asked Questions

1. What is 3C-P?

3C-P, or 3,5-Dimethoxy-4-propoxyamphetamine, is a lesser-known psychedelic substance belonging to the amphetamine class. It is the 3-carbon analog of proscaline, despite its name suggesting a potential relation to the 2C-x family.

2. When was 3C-P synthesized?

The original synthesis date of 3C-P is unknown. However, it is briefly mentioned in Alexander Shulgin's book PiHKAL, where its theoretical synthesis is outlined. Shulgin speculates on its psychedelic properties and suggests a dosage range of 20 to 40 milligrams.

3. How is 3C-P typically sold?

3C-P is commonly available on the online research chemical market.

4. What is known about the pharmacology of 3C-P?

3C-P interacts strongly with 5-HT2A receptors, suggesting potential applications in preventing cluster headaches or easing psychological suffering associated with end-stage cancer. It is considered a partial agonist at the 5-HT2A receptor, contributing to its psychedelic effects.

5. Is 3C-P related to the 2C-x family?

Contrary to its name, 3C-P is not related to the 2C-x family. Instead, it is the 3-carbon analog of proscaline.

6. What is the recommended dosage for 3C-P?

The suggested dosage range for 3C-P, as per Alexander Shulgin's speculation, is between 20 to 40 milligrams. However, caution is advised due to the limited data available on its pharmacological properties.

7. What are the potential risks associated with 3C-P?

Very little data exists about the metabolism and toxicity of 3C-P. As with any psychedelic substance, it is highly recommended to practice harm reduction and approach its usage with caution.

8. Where can I find more information about 3C-P?

Given its limited history and data, information about 3C-P is not extensively available. Researchers and the psychedelic community await further exploration to uncover more details about this compound.