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Table of Contents

Overview

• 1.1 Chemistry
• 1.2 Dosage
• 1.3 Pharmacology

Subjective Effects

• 2.1 Physical Effects
• 2.2 Cognitive Effects
• 2.3 Auditory Effects
• 2.4 Visual Effects
• 2.5 Hallucinatory States

Geometry

• 3.1 Visual Geometry
• 3.2 Hallucinatory States

Toxicity and Harm Potential

• 4.1 General Information
• 4.2 Tolerance and Addiction Potential
• 4.3 Dangerous Interactions

Legal Status

• 5.1 Global Overview
• 5.2 Specific Country Regulations

FAQ (Frequently Asked Questions)

• 6.1 What is 1P-ETH-LAD?
• 6.2 How does 1P-ETH-LAD differ from LSD?
• 6.3 What are the recommended dosages for 1P-ETH-LAD?
• 6.4 What are the potential side effects and risks?
• 6.5 Is 1P-ETH-LAD habit-forming?
• 6.6 How long does tolerance to 1P-ETH-LAD last?
• 6.7 Are there legal concerns associated with 1P-ETH-LAD?
• 6.8 Can 1P-ETH-LAD be used with other substances?

6.9 How should one approach harm reduction when using 1P-ETH-LAD?

Introduction

1-Propionyl-6-ethyl-6-nor-lysergic acid diethyamide, commonly known as 1P-ETH-LAD, belongs to the lysergamide chemical class and is a semisynthetic psychedelic substance. It is recognized as a designer drug analog and a suspected prodrug to ETH-LAD, sharing structural similarities with LSD and 1P-LSD. Anecdotal reports suggest that its psychedelic effects are comparable to ETH-LAD or AL-LAD.

Potency and Effects

Reports indicate that 1P-ETH-LAD is moderately to significantly more potent than LSD, similar to its parent compound ETH-LAD. Users describe it as having subtly different effects, being more visual and synaesthetic, with a less emotionally-charged headspace. However, it has been noted for a higher likelihood of inducing undesirable effects such as anxiety, thought loops, nausea, and other discomforting physical effects compared to other lysergamides.

Limited Data and History

Despite its increasing popularity, there is limited data on the pharmacological properties, metabolism, and toxicity of 1P-ETH-LAD. It emerged in human usage only after January 2016, making it a relatively recent addition to the psychedelic landscape. The compound is often marketed alongside other designer psychedelics, serving as a legal alternative to LSD, and is commercially distributed through online research chemical vendors.

Dosage Guidelines

Understanding the dosage is crucial for the safe use of 1P-ETH-LAD. Threshold effects are observed at 25 µg, with a light dose ranging from 30 to 60 µg. Common doses fall between 60 and 100 µg, while strong effects are experienced at doses of 100 to 200 µg. Heavy doses, exceeding 200 µg, should be approached with caution.

Pharmacology

The compound likely acts as a 5-HT2A partial agonist, with its psychedelic effects attributed to efficacy at the 5-HT2A receptors. 1P-ETH-LAD shares similarities with LSD, acting as a prodrug that transforms into ETH-LAD when incubated in human serum. The exact mechanisms underlying its psychedelic experience remain elusive, emphasizing the need for further research in understanding its pharmacology.

Chemistry

1-Propionyl-6-ethyl-6-nor-lysergic acid diethyamide, commonly known as 1P-ETH-LAD, belongs to the lysergamide chemical class. As a semisynthetic psychedelic substance, it is recognized as a designer drug analog and a suspected prodrug to ETH-LAD. Structurally related to LSD and 1P-LSD, anecdotal reports suggest that 1P-ETH-LAD produces psychedelic effects similar to ETH-LAD or AL-LAD.

Similar to its parent compound ETH-LAD, 1P-ETH-LAD is reported to be moderately to significantly more potent than LSD. Users describe it as having distinctive visual and synaesthetic effects, with a less emotionally-charged headspace compared to LSD. Reports also mention an increased likelihood of undesirable effects like anxiety, thought loops, nausea, and other physical discomforts.

Little data exists about the pharmacological properties, metabolism, and toxicity of 1P-ETH-LAD, with limited human usage history before January 2016. It has gained popularity as a legal alternative to LSD and is commercially available through online research chemical vendors.

Dosage

• Threshold: 25 µg
• Light: 30 - 60 µg
• Common: 60 - 100 µg
• Strong: 100 - 200 µg
• Heavy: 200 µg +

Pharmacology

1P-ETH-LAD likely acts as a 5-HT2A partial agonist, with psychedelic effects believed to stem from its efficacy at the 5-HT2A receptors. It shares similarities with LSD in potency and mechanism, but differences in metabolization may affect the progression and duration of effects. Research indicates the formation of ETH-LAD from 1P-ETH-LAD, suggesting prodrug functionality.

Subjective Effects

Physical Effects

• Stimulation: Energetic and stimulating, encouraging physical activities like running and dancing.
• Spontaneous Bodily Sensations: Intense euphoric tingling sensations, less sharp than LSD.
• Bodily Control Enhancement
• Increased Heart Rate
• Nausea: Mild, occasionally reported in moderate to high dosages.
• Pupil Dilation
• Tactile Enhancement: Consistently present at moderate levels.
• Teeth Grinding
• Temperature Regulation Suppression

• Cognitive Effects

• Analysis Enhancement
• Conceptual Thinking
• Delusion
• Déjà Vu
• Emotion Enhancement
• Immersion Enhancement
• Increased Music Appreciation
• Laughter
• Memory Suppression
• Ego Death
• Motivation Enhancement
• Novelty Enhancement
• Personal Bias Suppression
• Thought Acceleration
• Thought Loops
• Time Distortion
• Wakefulness

Auditory Effects

• Distortions
• Enhancements
• Hallucinations

Visual Effects

• Enhancements
• Colour Enhancement
• Pattern Recognition Enhancement
• Visual Acuity Enhancement

Distortions

• Drifting (Melting, Breathing, Morphing, and Flowing): Highly detailed yet cartoon-like, similar to LSD.
• After Images
• Colour Shifting
• Depth Perception Distortions
• Diffraction
• Scenery Slicing
• Symmetrical Texture Repetition
• Tracers 

Geometry and Legal Status

Geometry

1P-ETH-LAD's visual geometry is reminiscent of LSD, 2C-B, or 2C-I rather than psilocin, LSA, or DMT. Described as intricate, algorithmic, unstructured, brightly lit, and colorful, its geometry is organic, multicolored, flat-shaded, with soft edges. It appears large, slow in motion, and either angular or round in corners. The geometry is non-immersive in depth and maintains consistent intensity. At higher doses, it leans towards level 8B visual geometry over level 8A.

Compared to LSD, 1P-ETH-LAD's geometry is slightly softer, more rounded at the corners, and a bit less intricate while maintaining an overall identical appearance.

Hallucinatory States

1P-ETH-LAD can induce a broad range of hallucinatory states, somewhat less consistent than psychedelics like psilocin or DMT but more likely than LSD. Hallucinatory effects include transformations and internal hallucinations, which can be lucid, interactive, and diverse, ranging from personal to transcendental themes.

Toxicity and Harm Potential

The toxicity and long-term health effects of 1P-ETH-LAD remain unstudied in a scientific context due to its limited history of human usage as a research chemical. Anecdotal reports suggest no negative health effects at low to moderate doses, but caution is advised. Independent research is crucial for assessing the safety of substance combinations.

Tolerance and Addiction Potential

1P-ETH-LAD is not habit-forming, and the desire to use it may decrease with use. Tolerance builds almost immediately, with a physiological tolerance reduction to half after about 3 days, reaching baseline in 7 days. Mental or psychological tolerance may take two weeks or more for the full experience to re-manifest. Cross-tolerance with all psychedelics, particularly tryptamines and other lysergamides, is observed.

Dangerous Interactions

Caution is essential when combining 1P-ETH-LAD with certain substances. Some known dangerous interactions include:

• Lithium: Increases the risk of psychosis and seizures.
• Cannabis: May have a strong and unpredictable synergy, increasing the risk of adverse psychological reactions.
• Stimulants: Elevate the risk of anxiety, paranoia, panic attacks, thought loops, mania, and psychosis.
• Tramadol: Lowers the seizure threshold, potentially triggering seizures.

Legal Status

The legal status of 1P-ETH-LAD varies globally:

• Canada: Controlled as a Schedule III substance.
• Germany: Controlled under the NpSG as of July 18, 2019.
• Switzerland: Legal for scientific or industrial use.
• Turkey: Illegal to possess, produce, supply, or import.
• United States: Potentially illegal under the Federal Analogue Act.
• United Kingdom: Illegal to produce, supply, or import under the Psychoactive Substance Act since May 26, 2016.

FAQ (Frequently Asked Questions)

What is 1P-ETH-LAD?

1P-ETH-LAD is a semisynthetic psychedelic substance belonging to the lysergamide chemical class. It is often used as a legal alternative to LSD and shares structural similarities with ETH-LAD.

How does 1P-ETH-LAD differ from LSD?

While both substances belong to the lysergamide class and share similarities, users report that 1P-ETH-LAD has a slightly different effect profile, including being more visual and synaesthetic with a less emotionally-charged headspace compared to LSD.

What are the recommended dosages for 1P-ETH-LAD?

Dosages range from 25 µg (threshold) to 200 µg or more (heavy). Users are advised to start with lower doses and proceed cautiously due to variations in individual reactions.

What are the potential side effects and risks?

Reported side effects include anxiety, thought loops, nausea, and physical discomfort. At higher doses, hallucinatory states can occur. Limited research exists on its toxicity, and caution is advised.

Is 1P-ETH-LAD habit-forming?

1P-ETH-LAD is not considered habit-forming, and the desire to use it may decrease with use. It is thought to be self-regulating rather than self-reinforcing.

How long does tolerance to 1P-ETH-LAD last?

Physiological tolerance builds almost immediately and takes about 3 days to reduce to half. Mental or psychological tolerance may take two weeks or more to fully re-manifest.

Are there legal concerns associated with 1P-ETH-LAD?

Legal status varies globally, with some countries controlling it as a substance under drug regulations. Users should research and be aware of their local regulations.

Can 1P-ETH-LAD be used with other substances?

Caution is advised when combining 1P-ETH-LAD with other substances. Potential dangerous interactions include lithium, cannabis, stimulants, and tramadol.

How should one approach harm reduction when using 1P-ETH-LAD?

Harm reduction practices should include researching substance combinations, starting with lower doses, taking breaks between hits (if using cannabis), and being aware of potential adverse reactions. Always prioritize safety and seek medical assistance if needed.