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In recent years, synthetic cannabinoids have garnered prominence for their adverse effects on the human body. These synthetic medications are intended to replicate the effects of marijuana's natural cannabinoids, but their chemical structure is altogether different. Three synthetic cannabinoids have been offered as designer drugs: 5F-CUMYL-P7AICA (also known as CUMYL-5F-P7AICA or SGT-263), CUMYL-PEGACLONE (SGT-151), and 5F-CUMYL-PINACA (also known as SGT-25 and occasionally sold in e-cigarette form as C-Liquid). The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) discovered them for the first time in 2015, and their potential risks have been the subject of extensive research.

The Science behind Synthetic Cannabinoids

5F-CUMYL-P7AICA a synthetic cannabinoid based on pyrrolo[2,3-b]pyridine-3-carboxamide that mimics the effects of marijuana. It attaches to the same brain receptors as natural cannabinoids, causing comparable effects. Nonetheless, the chemical makeup is distinct and might have far stronger and more damaging effects on the human body.

CUMYL-PEGACLONE is a gamma-carboline-based synthetic cannabinoid whose structure is comparable to that of other gamma-carboline cannabinoids reported by Bristol-Myers Squibb in 2001. The gamma-carboline core structure had never been observed in a synthetic cannabinoid, making it impossible to anticipate its effects on the human body.

5F-CUMYL-PINACA is a potent agonist for cannabinoid receptors. It is an indazole-3-carboxamide-based synthetic cannabinoid. It binds to the CB1 and CB2 receptors in the brain and produces effects comparable to those of natural cannabinoids. However, 5F-CUMYL-PINACA is far more potent, with original patents claiming a selectivity of about 4x for CB1 and EC50 values of 0.1 nM for human CB1 receptors and 0.37 nM for human CB2 receptors. Recent experiments have discovered varied EC50 values for CB1 and CB2; however, these values cannot be directly compared due to the various assay methodologies employed.

The Dangers of Synthetic Cannabinoids

The use of synthetic cannabinoids can result in severe health issues, such as convulsions, hallucinations, an elevated heart rate, vomiting, and in rare circumstances, death. Due to the intensity of the chemicals employed in the medications and the fact that they bind to brain receptors considerably more strongly than natural cannabinoids, these severe side effects are produced.

What are the long-term consequences of synthetic cannabis use?

Since synthetic cannabinoids are relatively new and have not been fully explored, their long-term consequences are unknown. However, many studies indicate that they can harm the brain and other organs, resulting in long-term health issues. In addition, the unpredictable nature of the compounds utilized in these medications makes it impossible to determine the long-term consequences.